CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells

CD44 Interacts with HIF-2α to Modulate the Hypoxic Phenotype of Perinecrotic and Perivascular Glioma Cells

Hypoxia-inducible factors enhance glioma stemness, and glioma stem cells have an amplified hypoxic response despite residing within a perivascular niche. Still, little is known about differential HIF regulation in stem versus bulk glioma cells. We show that the intracellular domain of stem cell mark...

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Bibliographic Details
Main Authors: Elinn Johansson, Elisa S. Grassi, Vasiliki Pantazopoulou, Bei Tong, David Lindgren, Tracy J. Berg, Elin J. Pietras, Håkan Axelson, Alexander Pietras
Format: Article
Language:English
Published: Elsevier 2017-08-01
Series:Cell Reports
Subjects:
glioma
CD44
hypoxia
HIF-2α
HIF-1α
stemness
perivascular niche
stem cell niche
hypoxic niche
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310288

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