Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity
Antiretroviral therapy suppresses HIV replication but leaves a population of infected CD4+ T cells with integrated proviruses. While most of these proviruses contain defects, such as deletions, some intact proviruses persist and can reinitiate viral replication. In this issue of the JCI, Duette, Hie...
| Main Authors: | , |
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| Format: | Article |
| Language: | English |
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American Society for Clinical Investigation
2022-04-01
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| Series: | The Journal of Clinical Investigation |
| Online Access: | https://doi.org/10.1172/JCI158872 |
| _version_ | 1811326466556690432 |
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| author | Louise Leyre R. Brad Jones |
| author_facet | Louise Leyre R. Brad Jones |
| author_sort | Louise Leyre |
| collection | DOAJ |
| description | Antiretroviral therapy suppresses HIV replication but leaves a population of infected CD4+ T cells with integrated proviruses. While most of these proviruses contain defects, such as deletions, some intact proviruses persist and can reinitiate viral replication. In this issue of the JCI, Duette, Hiener, and colleagues performed a tour de force proviral landscape analysis on clinical samples collected over many years with in vitro functional assays. The researchers showed that effector memory CD4+ T cells provide partial sanctuary to intact proviruses from CD8+ T cells and this was associated with superior Nef-mediated MHC-I downregulation relative to less mature CD4+ T cell populations. This finding implicates differential immunoevasion as a cell-intrinsic property, influencing proviral persistence, and highlights Nef as a therapeutic target. |
| first_indexed | 2024-04-13T14:50:42Z |
| format | Article |
| id | doaj.art-5576f723d4c647e58dc7f0a968584bfa |
| institution | Directory Open Access Journal |
| issn | 1558-8238 |
| language | English |
| last_indexed | 2024-04-13T14:50:42Z |
| publishDate | 2022-04-01 |
| publisher | American Society for Clinical Investigation |
| record_format | Article |
| series | The Journal of Clinical Investigation |
| spelling | doaj.art-5576f723d4c647e58dc7f0a968584bfa2022-12-22T02:42:37ZengAmerican Society for Clinical InvestigationThe Journal of Clinical Investigation1558-82382022-04-011327Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturityLouise LeyreR. Brad JonesAntiretroviral therapy suppresses HIV replication but leaves a population of infected CD4+ T cells with integrated proviruses. While most of these proviruses contain defects, such as deletions, some intact proviruses persist and can reinitiate viral replication. In this issue of the JCI, Duette, Hiener, and colleagues performed a tour de force proviral landscape analysis on clinical samples collected over many years with in vitro functional assays. The researchers showed that effector memory CD4+ T cells provide partial sanctuary to intact proviruses from CD8+ T cells and this was associated with superior Nef-mediated MHC-I downregulation relative to less mature CD4+ T cell populations. This finding implicates differential immunoevasion as a cell-intrinsic property, influencing proviral persistence, and highlights Nef as a therapeutic target.https://doi.org/10.1172/JCI158872 |
| spellingShingle | Louise Leyre R. Brad Jones Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity The Journal of Clinical Investigation |
| title | Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity |
| title_full | Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity |
| title_fullStr | Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity |
| title_full_unstemmed | Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity |
| title_short | Hide and seek: for HIV-infected CD4+ T cells, playing well comes with maturity |
| title_sort | hide and seek for hiv infected cd4 t cells playing well comes with maturity |
| url | https://doi.org/10.1172/JCI158872 |
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