Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation

Activation of RAF1 (c-RAF) by the Marine Alkaloid Lasonolide A Induces Rapid Premature Chromosome Condensation

Lasonolide A (LSA), a potent antitumor polyketide from the marine sponge, Forcepia sp., induces rapid and reversible protein hyperphosphorylation and premature chromosome condensation (PCC) at nanomolar concentrations independent of cyclin-dependent kinases. To identify cellular targets of LSA, we...

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Bibliographic Details
Main Authors: Rozenn Jossé, Yong-Wei Zhang, Valentin Giroux, Arun K. Ghosh, Ji Luo, Yves Pommier
Format: Article
Language:English
Published: MDPI AG 2015-06-01
Series:Marine Drugs
Subjects:
chromosome condensation
c-raf
lasonolide A
shRNA
myosin phosphatase
Online Access:http://www.mdpi.com/1660-3397/13/6/3625

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