Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease
Muscle wasting and hyperphosphatemia are becoming increasingly prevalent in patients who exhibit a progressive decline in kidney function. However, the association between serum phosphate (Pi) level and sarcopenia in advanced chronic kidney disease (CKD) patients remains unclear. We compared the ser...
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| Format: | Article |
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MDPI AG
2021-10-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/10/3605 |
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| author | Ping-Huang Tsai Hsiu-Chien Yang Chin Lin Chih-Chien Sung Pauling Chu Yu-Juei Hsu |
| author_facet | Ping-Huang Tsai Hsiu-Chien Yang Chin Lin Chih-Chien Sung Pauling Chu Yu-Juei Hsu |
| author_sort | Ping-Huang Tsai |
| collection | DOAJ |
| description | Muscle wasting and hyperphosphatemia are becoming increasingly prevalent in patients who exhibit a progressive decline in kidney function. However, the association between serum phosphate (Pi) level and sarcopenia in advanced chronic kidney disease (CKD) patients remains unclear. We compared the serum Pi levels between advanced CKD patients with (<i>n</i> = 51) and those without sarcopenia indicators (<i>n</i> = 83). Low appendicular skeletal muscle mass index (ASMI), low handgrip strength, and low gait speed were defined per the standards of the Asian Working Group for Sarcopenia. Mean serum Pi level was significantly higher in advanced CKD patients with sarcopenia indicators than those without sarcopenia indicators (3.88 ± 0.86 vs. 3.54 ± 0.73 mg/dL; <i>p</i> = 0.016). Univariate analysis indicated that serum Pi was negatively correlated with ASMI, handgrip strength, and gait speed. Multivariable analysis revealed that serum Pi was significantly associated with handgrip strength (standardized β = −0.168; <i>p</i> = 0.022) and this association persisted even after adjustments for potential confounders. The optimal serum Pi cutoff for predicting low handgrip strength was 3.65 mg/dL, with a sensitivity of 82.1% and specificity of 56.6%. In summary, low handgrip strength is common in advanced CKD patients and serum Pi level is negatively associated with handgrip strength. |
| first_indexed | 2024-03-10T06:18:08Z |
| format | Article |
| id | doaj.art-5579022c54b1466ab7298e0fd647671f |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T06:18:08Z |
| publishDate | 2021-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-5579022c54b1466ab7298e0fd647671f2023-11-22T19:31:17ZengMDPI AGNutrients2072-66432021-10-011310360510.3390/nu13103605Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney DiseasePing-Huang Tsai0Hsiu-Chien Yang1Chin Lin2Chih-Chien Sung3Pauling Chu4Yu-Juei Hsu5Division of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDivision of Nephrology, Department of Internal Medicine, Zuoying Branch of Kaohsiung Armed Forces General Hospital, Kaohsiung 81342, TaiwanSchool of Public Health, National Defense Medical Center, Taipei 114, TaiwanDivision of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDivision of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanDivision of Nephrology, Department of Internal Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei 114, TaiwanMuscle wasting and hyperphosphatemia are becoming increasingly prevalent in patients who exhibit a progressive decline in kidney function. However, the association between serum phosphate (Pi) level and sarcopenia in advanced chronic kidney disease (CKD) patients remains unclear. We compared the serum Pi levels between advanced CKD patients with (<i>n</i> = 51) and those without sarcopenia indicators (<i>n</i> = 83). Low appendicular skeletal muscle mass index (ASMI), low handgrip strength, and low gait speed were defined per the standards of the Asian Working Group for Sarcopenia. Mean serum Pi level was significantly higher in advanced CKD patients with sarcopenia indicators than those without sarcopenia indicators (3.88 ± 0.86 vs. 3.54 ± 0.73 mg/dL; <i>p</i> = 0.016). Univariate analysis indicated that serum Pi was negatively correlated with ASMI, handgrip strength, and gait speed. Multivariable analysis revealed that serum Pi was significantly associated with handgrip strength (standardized β = −0.168; <i>p</i> = 0.022) and this association persisted even after adjustments for potential confounders. The optimal serum Pi cutoff for predicting low handgrip strength was 3.65 mg/dL, with a sensitivity of 82.1% and specificity of 56.6%. In summary, low handgrip strength is common in advanced CKD patients and serum Pi level is negatively associated with handgrip strength.https://www.mdpi.com/2072-6643/13/10/3605chronic kidney diseasehyperphosphatemiasarcopeniabioimpedancehandgrip strength |
| spellingShingle | Ping-Huang Tsai Hsiu-Chien Yang Chin Lin Chih-Chien Sung Pauling Chu Yu-Juei Hsu Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease Nutrients chronic kidney disease hyperphosphatemia sarcopenia bioimpedance handgrip strength |
| title | Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease |
| title_full | Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease |
| title_fullStr | Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease |
| title_full_unstemmed | Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease |
| title_short | Association of Serum Phosphate with Low Handgrip Strength in Patients with Advanced Chronic Kidney Disease |
| title_sort | association of serum phosphate with low handgrip strength in patients with advanced chronic kidney disease |
| topic | chronic kidney disease hyperphosphatemia sarcopenia bioimpedance handgrip strength |
| url | https://www.mdpi.com/2072-6643/13/10/3605 |
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