The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials
We aimed to systematically review the effectiveness of probiotic/synbiotic formulations to counteract cardiometabolic risk (CMR) in healthy people not receiving adjunctive medication. The systematic search (PubMed/MEDLINE/Embase) until 1 August 2019 was performed for randomized controlled trials in...
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| Format: | Article |
| Language: | English |
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MDPI AG
2020-06-01
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| Series: | Journal of Clinical Medicine |
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| Online Access: | https://www.mdpi.com/2077-0383/9/6/1788 |
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| author | Karolina Skonieczna-Żydecka Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Joanna Śliwa-Dominiak Dominika Maciejewska Katarzyna Janda Ewa Stachowska Beata Łoniewska Damian Malinowski Krzysztof Borecki Wojciech Marlicz Igor Łoniewski |
| author_facet | Karolina Skonieczna-Żydecka Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Joanna Śliwa-Dominiak Dominika Maciejewska Katarzyna Janda Ewa Stachowska Beata Łoniewska Damian Malinowski Krzysztof Borecki Wojciech Marlicz Igor Łoniewski |
| author_sort | Karolina Skonieczna-Żydecka |
| collection | DOAJ |
| description | We aimed to systematically review the effectiveness of probiotic/synbiotic formulations to counteract cardiometabolic risk (CMR) in healthy people not receiving adjunctive medication. The systematic search (PubMed/MEDLINE/Embase) until 1 August 2019 was performed for randomized controlled trials in >20 adult patients. Random-effect meta-analysis subgroup and meta-regression analysis of co-primary (haemoglobin A1c (HbA1C), glucose, insulin, body weight, waist circumference (WC), body mass index (BMI), cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, and blood pressure) and secondary outcomes (uric acid, plasminogen activator inhibitor-1–PAI-1, fibrinogen, and any variable related to inflammation/endothelial dysfunction). We included 61 trials (5422 persons). The mean time of probiotic administration was 67.01 ± 38.72 days. Most of probiotic strains were of <i>Lactobacillus</i> and <i>Bifidobacterium</i> genera. The other strains were <i>Streptococci</i>, <i>Enterococci</i>, and <i>Pediococci</i>. The daily probiotic dose varied between 10<sup>6</sup> and 10<sup>10</sup> colony-forming units (CFU)/gram. Probiotics/synbiotics counteracted CMR factors (endpoint data on BMI: standardized mean difference (SMD) = −0.156, <i>p</i> = 0.006 and difference in means (DM) = −0.45, <i>p</i> = 0.00 and on WC: SMD = −0.147, <i>p</i> = 0.05 and DM = −1.21, <i>p</i> = 0.02; change scores on WC: SMD = −0.166, <i>p</i> = 0.04 and DM = −1.35, <i>p</i> = 0.03) in healthy persons. Overweight/obese healthy people might additionally benefit from reducing total cholesterol concentration (change scores on WC in overweight/obese: SMD: −0.178, <i>p</i> = 0.049). Poor quality of probiotic-related trials make systematic reviews and meta-analyses difficult to conduct and draw definite conclusions. “Gold standard” methodology in probiotic studies awaits further development. |
| first_indexed | 2024-03-10T19:17:52Z |
| format | Article |
| id | doaj.art-557a2a0d37594d748a21cdbb81d31365 |
| institution | Directory Open Access Journal |
| issn | 2077-0383 |
| language | English |
| last_indexed | 2024-03-10T19:17:52Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Clinical Medicine |
| spelling | doaj.art-557a2a0d37594d748a21cdbb81d313652023-11-20T03:13:40ZengMDPI AGJournal of Clinical Medicine2077-03832020-06-0196178810.3390/jcm9061788The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled TrialsKarolina Skonieczna-Żydecka0Karolina Kaźmierczak-Siedlecka1Mariusz Kaczmarczyk2Joanna Śliwa-Dominiak3Dominika Maciejewska4Katarzyna Janda5Ewa Stachowska6Beata Łoniewska7Damian Malinowski8Krzysztof Borecki9Wojciech Marlicz10Igor Łoniewski11Department of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Surgical Oncology, Medical University of Gdansk, Smoluchowskiego 17, 80-214 Gdańsk, PolandDepartment of Clinical and Molecular Biochemistry, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandSanprobi sp. z o.o. sp. k. Kurza Stopka 5/c, 70-535 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Neonatal Diseases, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Pharmacology, Pomeranian Medical University in Szczecin, 70-111 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandDepartment of Gastroenterology, Pomeranian Medical University, 71-252 Szczecin, PolandDepartment of Human Nutrition and Metabolomics, Pomeranian Medical University in Szczecin, 71-460 Szczecin, PolandWe aimed to systematically review the effectiveness of probiotic/synbiotic formulations to counteract cardiometabolic risk (CMR) in healthy people not receiving adjunctive medication. The systematic search (PubMed/MEDLINE/Embase) until 1 August 2019 was performed for randomized controlled trials in >20 adult patients. Random-effect meta-analysis subgroup and meta-regression analysis of co-primary (haemoglobin A1c (HbA1C), glucose, insulin, body weight, waist circumference (WC), body mass index (BMI), cholesterol, low-density lipoproteins (LDL), high-density lipoproteins (HDL), triglycerides, and blood pressure) and secondary outcomes (uric acid, plasminogen activator inhibitor-1–PAI-1, fibrinogen, and any variable related to inflammation/endothelial dysfunction). We included 61 trials (5422 persons). The mean time of probiotic administration was 67.01 ± 38.72 days. Most of probiotic strains were of <i>Lactobacillus</i> and <i>Bifidobacterium</i> genera. The other strains were <i>Streptococci</i>, <i>Enterococci</i>, and <i>Pediococci</i>. The daily probiotic dose varied between 10<sup>6</sup> and 10<sup>10</sup> colony-forming units (CFU)/gram. Probiotics/synbiotics counteracted CMR factors (endpoint data on BMI: standardized mean difference (SMD) = −0.156, <i>p</i> = 0.006 and difference in means (DM) = −0.45, <i>p</i> = 0.00 and on WC: SMD = −0.147, <i>p</i> = 0.05 and DM = −1.21, <i>p</i> = 0.02; change scores on WC: SMD = −0.166, <i>p</i> = 0.04 and DM = −1.35, <i>p</i> = 0.03) in healthy persons. Overweight/obese healthy people might additionally benefit from reducing total cholesterol concentration (change scores on WC in overweight/obese: SMD: −0.178, <i>p</i> = 0.049). Poor quality of probiotic-related trials make systematic reviews and meta-analyses difficult to conduct and draw definite conclusions. “Gold standard” methodology in probiotic studies awaits further development.https://www.mdpi.com/2077-0383/9/6/1788probioticsynbioticmicrobiotacardiometabolic |
| spellingShingle | Karolina Skonieczna-Żydecka Karolina Kaźmierczak-Siedlecka Mariusz Kaczmarczyk Joanna Śliwa-Dominiak Dominika Maciejewska Katarzyna Janda Ewa Stachowska Beata Łoniewska Damian Malinowski Krzysztof Borecki Wojciech Marlicz Igor Łoniewski The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials Journal of Clinical Medicine probiotic synbiotic microbiota cardiometabolic |
| title | The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials |
| title_full | The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials |
| title_fullStr | The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials |
| title_full_unstemmed | The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials |
| title_short | The Effect of Probiotics and Synbiotics on Risk Factors Associated with Cardiometabolic Diseases in Healthy People—A Systematic Review and Meta-Analysis with Meta-Regression of Randomized Controlled Trials |
| title_sort | effect of probiotics and synbiotics on risk factors associated with cardiometabolic diseases in healthy people a systematic review and meta analysis with meta regression of randomized controlled trials |
| topic | probiotic synbiotic microbiota cardiometabolic |
| url | https://www.mdpi.com/2077-0383/9/6/1788 |
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