The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome
Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the loss of self-tolerance mechanisms in various autoimmune diseases, including primary Sjögren’s syndrome (pSS). With the development of pSS primarily in the exocrine glands, lymphocytic infiltration occurs in t...
| Prif Awduron: | , , , |
|---|---|
| Fformat: | Erthygl |
| Iaith: | English |
| Cyhoeddwyd: |
MDPI AG
2023-05-01
|
| Cyfres: | Cells |
| Pynciau: | |
| Mynediad Ar-lein: | https://www.mdpi.com/2073-4409/12/10/1359 |
| _version_ | 1827741759286804480 |
|---|---|
| author | Varvara G. Blinova Vladimir I. Vasilyev Ekaterina B. Rodionova Dmitry D. Zhdanov |
| author_facet | Varvara G. Blinova Vladimir I. Vasilyev Ekaterina B. Rodionova Dmitry D. Zhdanov |
| author_sort | Varvara G. Blinova |
| collection | DOAJ |
| description | Regulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the loss of self-tolerance mechanisms in various autoimmune diseases, including primary Sjögren’s syndrome (pSS). With the development of pSS primarily in the exocrine glands, lymphocytic infiltration occurs in the early stages, mainly due to activated CD4<sup>+</sup> T cells. Subsequently, in the absence of rational therapy, patients develop ectopic lymphoid structures and lymphomas. While the suppression of autoactivated CD4<sup>+</sup> T cells is involved in the pathological process, the main role belongs to Tregs, making them a target for research and possible regenerative therapy. However, the available information about their role in the onset and progression of this disease seems unsystematized and, in certain aspects, controversial. In our review, we aimed to organize the data on the role of Tregs in the pathogenesis of pSS, as well as to discuss possible strategies of cell therapy for this disease. This review provides information on the differentiation, activation, and suppressive functions of Tregs and the role of the FoxP3 protein in these processes. It also highlights data on various subpopulations of Tregs in pSS, their proportion in the peripheral blood and minor salivary glands of patients as well as their role in the development of ectopic lymphoid structures. Our data emphasize the need for further research on Tregs and highlight their potential use as a cell-based therapy. |
| first_indexed | 2024-03-11T03:51:37Z |
| format | Article |
| id | doaj.art-557ba5c5c5b84e1180147545ac66220e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T03:51:37Z |
| publishDate | 2023-05-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-557ba5c5c5b84e1180147545ac66220e2023-11-18T00:52:26ZengMDPI AGCells2073-44092023-05-011210135910.3390/cells12101359The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s SyndromeVarvara G. Blinova0Vladimir I. Vasilyev1Ekaterina B. Rodionova2Dmitry D. Zhdanov3Laboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, RussiaJoint and Heart Treatment Center, Nizhnyaya Krasnoselskaya St. 4, 107140 Moscow, RussiaMedical Center Ltd., Timura Frunze St. 15/1, 119021 Moscow, RussiaLaboratory of Medical Biotechnology, Institute of Biomedical Chemistry, Pogodinskaya St. 10/8, 119121 Moscow, RussiaRegulatory T cells (Tregs) play a key role in maintaining immune balance and regulating the loss of self-tolerance mechanisms in various autoimmune diseases, including primary Sjögren’s syndrome (pSS). With the development of pSS primarily in the exocrine glands, lymphocytic infiltration occurs in the early stages, mainly due to activated CD4<sup>+</sup> T cells. Subsequently, in the absence of rational therapy, patients develop ectopic lymphoid structures and lymphomas. While the suppression of autoactivated CD4<sup>+</sup> T cells is involved in the pathological process, the main role belongs to Tregs, making them a target for research and possible regenerative therapy. However, the available information about their role in the onset and progression of this disease seems unsystematized and, in certain aspects, controversial. In our review, we aimed to organize the data on the role of Tregs in the pathogenesis of pSS, as well as to discuss possible strategies of cell therapy for this disease. This review provides information on the differentiation, activation, and suppressive functions of Tregs and the role of the FoxP3 protein in these processes. It also highlights data on various subpopulations of Tregs in pSS, their proportion in the peripheral blood and minor salivary glands of patients as well as their role in the development of ectopic lymphoid structures. Our data emphasize the need for further research on Tregs and highlight their potential use as a cell-based therapy.https://www.mdpi.com/2073-4409/12/10/1359regulatory T cellsprimary Sjögren’s syndromeFoxP3Treg-based therapy |
| spellingShingle | Varvara G. Blinova Vladimir I. Vasilyev Ekaterina B. Rodionova Dmitry D. Zhdanov The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome Cells regulatory T cells primary Sjögren’s syndrome FoxP3 Treg-based therapy |
| title | The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome |
| title_full | The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome |
| title_fullStr | The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome |
| title_full_unstemmed | The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome |
| title_short | The Role of Regulatory T Cells in the Onset and Progression of Primary Sjögren’s Syndrome |
| title_sort | role of regulatory t cells in the onset and progression of primary sjogren s syndrome |
| topic | regulatory T cells primary Sjögren’s syndrome FoxP3 Treg-based therapy |
| url | https://www.mdpi.com/2073-4409/12/10/1359 |
| work_keys_str_mv | AT varvaragblinova theroleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT vladimirivasilyev theroleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT ekaterinabrodionova theroleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT dmitrydzhdanov theroleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT varvaragblinova roleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT vladimirivasilyev roleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT ekaterinabrodionova roleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome AT dmitrydzhdanov roleofregulatorytcellsintheonsetandprogressionofprimarysjogrenssyndrome |