Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases
Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher. Chemokines and cytokines affect different stages...
| Main Authors: | , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2021-06-01
|
| Series: | Biomedicines |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2227-9059/9/6/659 |
| _version_ | 1797530939400650752 |
|---|---|
| author | Paola Maroni Paola Bendinelli Anita Ferraretto Giovanni Lombardi |
| author_facet | Paola Maroni Paola Bendinelli Anita Ferraretto Giovanni Lombardi |
| author_sort | Paola Maroni |
| collection | DOAJ |
| description | Bone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher. Chemokines and cytokines affect different stages of the metastatic process, and in bone metastases, interleukin (IL) -6, IL-8, IL-1β, and IL-11 participate in the interaction between cancer cells and bone cells. This review focuses on IL-11, a pleiotropic cytokine that, in addition to its well-known effects on several tissues, also mediates certain signals in cancer cells. In particular, as IL-11 works on bone remodeling, it plays a relevant role in the osteolytic vicious cycle of bone resorption and tumour growth, which characterizes bone metastasis. IL-11 appears as a candidate for anti-metastatic therapy. Even if different therapeutic approaches have considered IL-11 and the downstream-activated gp130 signaling pathways activated downstream of gp130, further studies are needed to decipher the contribution of the different cytokines and their mechanisms of action in breast cancer progression to define therapeutic strategies. |
| first_indexed | 2024-03-10T10:37:04Z |
| format | Article |
| id | doaj.art-557e2220494c463faea5690a11b24c6e |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-10T10:37:04Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-557e2220494c463faea5690a11b24c6e2023-11-21T23:15:33ZengMDPI AGBiomedicines2227-90592021-06-019665910.3390/biomedicines9060659Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone MetastasesPaola Maroni0Paola Bendinelli1Anita Ferraretto2Giovanni Lombardi3Laboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milano, ItalyDipartimento di Scienze Biomediche per la Salute, Università degli Studi di Milano, Via L. Mangiagalli 31, 20133 Milano, ItalyLaboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milano, ItalyLaboratory of Experimental Biochemistry and Molecular Biology, IRCCS Istituto Ortopedico Galeazzi, Via R. Galeazzi 4, 20161 Milano, ItalyBone metastases represent the main problem related to the progression of breast cancer, as they are the main cause of death for these patients. Unfortunately, to date, bone metastases are incurable and represent the main challenge for the researcher. Chemokines and cytokines affect different stages of the metastatic process, and in bone metastases, interleukin (IL) -6, IL-8, IL-1β, and IL-11 participate in the interaction between cancer cells and bone cells. This review focuses on IL-11, a pleiotropic cytokine that, in addition to its well-known effects on several tissues, also mediates certain signals in cancer cells. In particular, as IL-11 works on bone remodeling, it plays a relevant role in the osteolytic vicious cycle of bone resorption and tumour growth, which characterizes bone metastasis. IL-11 appears as a candidate for anti-metastatic therapy. Even if different therapeutic approaches have considered IL-11 and the downstream-activated gp130 signaling pathways activated downstream of gp130, further studies are needed to decipher the contribution of the different cytokines and their mechanisms of action in breast cancer progression to define therapeutic strategies.https://www.mdpi.com/2227-9059/9/6/659interleukin 11 (IL-11)bone metastasisbreast cancerboneosteolysis |
| spellingShingle | Paola Maroni Paola Bendinelli Anita Ferraretto Giovanni Lombardi Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases Biomedicines interleukin 11 (IL-11) bone metastasis breast cancer bone osteolysis |
| title | Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases |
| title_full | Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases |
| title_fullStr | Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases |
| title_full_unstemmed | Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases |
| title_short | Interleukin 11 (IL-11): Role(s) in Breast Cancer Bone Metastases |
| title_sort | interleukin 11 il 11 role s in breast cancer bone metastases |
| topic | interleukin 11 (IL-11) bone metastasis breast cancer bone osteolysis |
| url | https://www.mdpi.com/2227-9059/9/6/659 |
| work_keys_str_mv | AT paolamaroni interleukin11il11rolesinbreastcancerbonemetastases AT paolabendinelli interleukin11il11rolesinbreastcancerbonemetastases AT anitaferraretto interleukin11il11rolesinbreastcancerbonemetastases AT giovannilombardi interleukin11il11rolesinbreastcancerbonemetastases |