Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE2-dependent IgE inhibition in pancreatic cancerResearch in context

Pro-tumor Tfh2 cells induce detrimental IgG4 production and PGE2-dependent IgE inhibition in pancreatic cancerResearch in context

Summary: Background: Pancreatic ductal adenocarcinoma (PDAC) has a dismal prognosis and it is characterized by predominant pro-tumor Th2-type inflammation. T follicular helper (Tfh) cells are relevant immunoregulators in cancer, and often correlate with better survival. How the Th2-skewed microenvi...

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Bibliographic Details
Main Authors: Lucia De Monte, Francesca Clemente, Eliana Ruggiero, Raffaella Pini, Maria Grazia Ceraolo, Marco Schiavo Lena, Chiara Balestrieri, Dejan Lazarevic, Giulio Belfiori, Stefano Crippa, Gianpaolo Balzano, Massimo Falconi, Claudio Doglioni, Chiara Bonini, Michele Reni, Maria Pia Protti
Format: Article
Language:English
Published: Elsevier 2023-11-01
Series:EBioMedicine
Subjects:
Pancreatic cancer
Th2 inflammation
Tfh2
IgG4
IgE
PGE2
Online Access:http://www.sciencedirect.com/science/article/pii/S2352396423003857

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