Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma
Abstract Background To analyze the diagnostic value of computed tomography (CT), magnetic resonance imaging (MRI) combined with serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and N-myc (MYCN) in the diagnosis of pediatric neuroblastoma. Methods Fift...
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| Format: | Article |
| Language: | English |
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BMC
2023-08-01
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| Series: | World Journal of Surgical Oncology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12957-023-03131-5 |
| _version_ | 1797559247842574336 |
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| author | Jumei Hao Jing Sang Xiajuan Xu Aihua Bao |
| author_facet | Jumei Hao Jing Sang Xiajuan Xu Aihua Bao |
| author_sort | Jumei Hao |
| collection | DOAJ |
| description | Abstract Background To analyze the diagnostic value of computed tomography (CT), magnetic resonance imaging (MRI) combined with serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and N-myc (MYCN) in the diagnosis of pediatric neuroblastoma. Methods Fifty-two children diagnosed with neuroblastoma were selected as the neuroblastoma group. During the same period, 52 children who visited our hospital with abdominal distension, diarrhea, constipation, and vomiting but were finally excluded from neuroblastoma were selected as the control group. CT and MRI were performed on all children. Results Fifty-two cases of neuroblastoma of the central nervous system were confirmed by pathological examination. The levels of LDH, NSE, CEA, and MYCN in the neuroblastoma group were clearly higher than those in the control group (P < 0.05). The results of CT and MRI combined with serum LDH, NSE, CEA, and MYCN were false positive in 10 cases and false negative in 6 cases, which were consistent with the pathological results. The sensitivity of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in the diagnosis of neuroblastoma was notably higher than that of the three alone (P < 0.05). Conclusion The imaging findings of CT and MRI in children with central nervous system neuroblastoma were definitely characteristic. MRI had higher diagnostic value than CT. The diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN was improved to some extent. |
| first_indexed | 2024-03-10T17:42:43Z |
| format | Article |
| id | doaj.art-557f7ee194cf4f0095753fe51e41d1fc |
| institution | Directory Open Access Journal |
| issn | 1477-7819 |
| language | English |
| last_indexed | 2024-03-10T17:42:43Z |
| publishDate | 2023-08-01 |
| publisher | BMC |
| record_format | Article |
| series | World Journal of Surgical Oncology |
| spelling | doaj.art-557f7ee194cf4f0095753fe51e41d1fc2023-11-20T09:37:22ZengBMCWorld Journal of Surgical Oncology1477-78192023-08-012111610.1186/s12957-023-03131-5Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastomaJumei Hao0Jing Sang1Xiajuan Xu2Aihua Bao3Department of Pediatrics, Yantaishan HospitalDepartment of ICU, Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer HospitalDepartment of Tumor Comprehensive Treatment (I), Affiliated Qingdao Central Hospital of Qingdao University, Qingdao Cancer HospitalMedical Imaging Department, Qingdao Women and Children’s HospitalAbstract Background To analyze the diagnostic value of computed tomography (CT), magnetic resonance imaging (MRI) combined with serum lactate dehydrogenase (LDH), neuron-specific enolase (NSE), carcinoembryonic antigen (CEA), and N-myc (MYCN) in the diagnosis of pediatric neuroblastoma. Methods Fifty-two children diagnosed with neuroblastoma were selected as the neuroblastoma group. During the same period, 52 children who visited our hospital with abdominal distension, diarrhea, constipation, and vomiting but were finally excluded from neuroblastoma were selected as the control group. CT and MRI were performed on all children. Results Fifty-two cases of neuroblastoma of the central nervous system were confirmed by pathological examination. The levels of LDH, NSE, CEA, and MYCN in the neuroblastoma group were clearly higher than those in the control group (P < 0.05). The results of CT and MRI combined with serum LDH, NSE, CEA, and MYCN were false positive in 10 cases and false negative in 6 cases, which were consistent with the pathological results. The sensitivity of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in the diagnosis of neuroblastoma was notably higher than that of the three alone (P < 0.05). Conclusion The imaging findings of CT and MRI in children with central nervous system neuroblastoma were definitely characteristic. MRI had higher diagnostic value than CT. The diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN was improved to some extent.https://doi.org/10.1186/s12957-023-03131-5NeuroblastomaPathological examinationCTMRIMYCN |
| spellingShingle | Jumei Hao Jing Sang Xiajuan Xu Aihua Bao Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma World Journal of Surgical Oncology Neuroblastoma Pathological examination CT MRI MYCN |
| title | Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma |
| title_full | Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma |
| title_fullStr | Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma |
| title_full_unstemmed | Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma |
| title_short | Diagnostic value of CT and MRI combined with serum LDH, NSE, CEA, and MYCN in pediatric neuroblastoma |
| title_sort | diagnostic value of ct and mri combined with serum ldh nse cea and mycn in pediatric neuroblastoma |
| topic | Neuroblastoma Pathological examination CT MRI MYCN |
| url | https://doi.org/10.1186/s12957-023-03131-5 |
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