Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features
Prescription drug abuse is an issue that is rapidly growing globally. Pregabalin, an anticonvulsant, analgesic, and anxiolytic medication, is effective in the management of multiple neurological disorders; however, there is increasing concern regarding its widespread illicit use. It has been previou...
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| Format: | Article |
| Language: | English |
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Elsevier
2024-02-01
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| Series: | Saudi Pharmaceutical Journal |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1319016423004309 |
| _version_ | 1827344831112806400 |
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| author | Yusuf S. Althobaiti |
| author_facet | Yusuf S. Althobaiti |
| author_sort | Yusuf S. Althobaiti |
| collection | DOAJ |
| description | Prescription drug abuse is an issue that is rapidly growing globally. Pregabalin, an anticonvulsant, analgesic, and anxiolytic medication, is effective in the management of multiple neurological disorders; however, there is increasing concern regarding its widespread illicit use. It has been previously reported in mice that pregabalin can induce conditioned place preference. In this current investigation, the potential of pregabalin to elicit free-choice drinking in a mouse model of drug addiction, and its effect on recognition and withdrawal behaviors after forced abstinence, were studied. Twenty-two male BALB/c mice were randomly divided into three groups (n = 7–8/group); control, pregabalin-30, and pregabalin-60. The study had three phases: habituation (days 1–5) with free water access, free-choice drinking (days 6–13) with pregabalin groups receiving one water and one pregabalin bottle, and forced abstinence (days 14–21) with free water access. On day 13, the first open field test was conducted, followed by the Novel Object Recognition Test. On day 21, the second open field test was performed, followed by the Tail Suspension Test and Forced Swimming Test. Pregabalin elicited voluntary drinking in the higher-dose group, concurrently causing a decline in recognition memory performance in the novel object recognition test. Moreover, pregabalin induced withdrawal behavior after a period of forced abstinence in the forced swimming and tail suspension tests. This is the first report to establish an animal model of free-choice pregabalin drinking that may be used for further molecular studies and targeted therapy for pregabalin addiction. |
| first_indexed | 2024-03-07T22:55:16Z |
| format | Article |
| id | doaj.art-55800674c10846fc80979fa8ad0f8343 |
| institution | Directory Open Access Journal |
| issn | 1319-0164 |
| language | English |
| last_indexed | 2024-03-07T22:55:16Z |
| publishDate | 2024-02-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Saudi Pharmaceutical Journal |
| spelling | doaj.art-55800674c10846fc80979fa8ad0f83432024-02-23T04:58:49ZengElsevierSaudi Pharmaceutical Journal1319-01642024-02-01322101935Oral self-administration of pregabalin in a mouse model and the resulting drug addiction featuresYusuf S. Althobaiti0Address: Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia.; Department of Pharmacology and Toxicology, College of Pharmacy, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia; Addiction and Neuroscience Research Unit, Taif University, Taif, Saudi Arabia; General Administration for Precursors and Laboratories, Ministry of Interior, General Directorate of Narcotics Control, Riyadh, Saudi ArabiaPrescription drug abuse is an issue that is rapidly growing globally. Pregabalin, an anticonvulsant, analgesic, and anxiolytic medication, is effective in the management of multiple neurological disorders; however, there is increasing concern regarding its widespread illicit use. It has been previously reported in mice that pregabalin can induce conditioned place preference. In this current investigation, the potential of pregabalin to elicit free-choice drinking in a mouse model of drug addiction, and its effect on recognition and withdrawal behaviors after forced abstinence, were studied. Twenty-two male BALB/c mice were randomly divided into three groups (n = 7–8/group); control, pregabalin-30, and pregabalin-60. The study had three phases: habituation (days 1–5) with free water access, free-choice drinking (days 6–13) with pregabalin groups receiving one water and one pregabalin bottle, and forced abstinence (days 14–21) with free water access. On day 13, the first open field test was conducted, followed by the Novel Object Recognition Test. On day 21, the second open field test was performed, followed by the Tail Suspension Test and Forced Swimming Test. Pregabalin elicited voluntary drinking in the higher-dose group, concurrently causing a decline in recognition memory performance in the novel object recognition test. Moreover, pregabalin induced withdrawal behavior after a period of forced abstinence in the forced swimming and tail suspension tests. This is the first report to establish an animal model of free-choice pregabalin drinking that may be used for further molecular studies and targeted therapy for pregabalin addiction.http://www.sciencedirect.com/science/article/pii/S1319016423004309PregabalinDrug addictionTail suspension testFree-choice drinkingNovel object recognition testForced swimming test |
| spellingShingle | Yusuf S. Althobaiti Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features Saudi Pharmaceutical Journal Pregabalin Drug addiction Tail suspension test Free-choice drinking Novel object recognition test Forced swimming test |
| title | Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features |
| title_full | Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features |
| title_fullStr | Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features |
| title_full_unstemmed | Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features |
| title_short | Oral self-administration of pregabalin in a mouse model and the resulting drug addiction features |
| title_sort | oral self administration of pregabalin in a mouse model and the resulting drug addiction features |
| topic | Pregabalin Drug addiction Tail suspension test Free-choice drinking Novel object recognition test Forced swimming test |
| url | http://www.sciencedirect.com/science/article/pii/S1319016423004309 |
| work_keys_str_mv | AT yusufsalthobaiti oralselfadministrationofpregabalininamousemodelandtheresultingdrugaddictionfeatures |