Effect of daily teriparatide for delayed union of fracture neck of the femur
Background: Delayed union and nonunion of fracture neck of the femur remains a therapeutic challenge to orthopedic surgeons worldwide which is why this fracture is aptly named as unsolved fracture. Hip joint preservation surgery always remains the primary criteria in fracture neck of the femur in ph...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2019-01-01
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| Series: | Journal of Orthopedics, Traumatology and Rehabilitation |
| Subjects: | |
| Online Access: | http://www.jotr.in/article.asp?issn=0975-7341;year=2019;volume=11;issue=1;spage=49;epage=52;aulast=Mishra |
| _version_ | 1818215805706305536 |
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| author | Jitendra Kumar Mishra Nirmal Chandra Mohapatra Bikram Keshari Kar |
| author_facet | Jitendra Kumar Mishra Nirmal Chandra Mohapatra Bikram Keshari Kar |
| author_sort | Jitendra Kumar Mishra |
| collection | DOAJ |
| description | Background: Delayed union and nonunion of fracture neck of the femur remains a therapeutic challenge to orthopedic surgeons worldwide which is why this fracture is aptly named as unsolved fracture. Hip joint preservation surgery always remains the primary criteria in fracture neck of the femur in physiologically young patients. However, the outcome is not always satisfactory due to many factors, delayed presentation being one of them. This case series was conducted to determine and establish the role of recombinant teriparatide in fracture healing in delayed union of fracture neck of the femur. Materials and Methods: The study was done on nine cases (six males and three females) of delayed union of fracture neck of the femur with a previous history of some surgical interventions. All cases of delayed union were diagnosed by clinically and radiologically and undergone all routine blood investigations. All were administered 20 μg of teriparatide (recombinant parathormone) subcutaneous injection daily for a period of 3–5 months. Results: Eight patients who were evaluated clinically and radiologically showed satisfactory union and one case showed nonunion. One patient showed mild allergic reaction. Conclusion: This study showed that daily administration of teriparatide accelerates fracture healing in delayed union. It also enhances fracture healing throughout the period of bone remodeling phase. It also emphasizes the safety of teriparatide. |
| first_indexed | 2024-12-12T06:41:55Z |
| format | Article |
| id | doaj.art-55807b979d50415894f1d1d3b36ddc1a |
| institution | Directory Open Access Journal |
| issn | 0975-7341 |
| language | English |
| last_indexed | 2024-12-12T06:41:55Z |
| publishDate | 2019-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Orthopedics, Traumatology and Rehabilitation |
| spelling | doaj.art-55807b979d50415894f1d1d3b36ddc1a2022-12-22T00:34:18ZengWolters Kluwer Medknow PublicationsJournal of Orthopedics, Traumatology and Rehabilitation0975-73412019-01-01111495210.4103/jotr.jotr_16_19Effect of daily teriparatide for delayed union of fracture neck of the femurJitendra Kumar MishraNirmal Chandra MohapatraBikram Keshari KarBackground: Delayed union and nonunion of fracture neck of the femur remains a therapeutic challenge to orthopedic surgeons worldwide which is why this fracture is aptly named as unsolved fracture. Hip joint preservation surgery always remains the primary criteria in fracture neck of the femur in physiologically young patients. However, the outcome is not always satisfactory due to many factors, delayed presentation being one of them. This case series was conducted to determine and establish the role of recombinant teriparatide in fracture healing in delayed union of fracture neck of the femur. Materials and Methods: The study was done on nine cases (six males and three females) of delayed union of fracture neck of the femur with a previous history of some surgical interventions. All cases of delayed union were diagnosed by clinically and radiologically and undergone all routine blood investigations. All were administered 20 μg of teriparatide (recombinant parathormone) subcutaneous injection daily for a period of 3–5 months. Results: Eight patients who were evaluated clinically and radiologically showed satisfactory union and one case showed nonunion. One patient showed mild allergic reaction. Conclusion: This study showed that daily administration of teriparatide accelerates fracture healing in delayed union. It also enhances fracture healing throughout the period of bone remodeling phase. It also emphasizes the safety of teriparatide.http://www.jotr.in/article.asp?issn=0975-7341;year=2019;volume=11;issue=1;spage=49;epage=52;aulast=Mishradelayed unionneck of femurteriparatide |
| spellingShingle | Jitendra Kumar Mishra Nirmal Chandra Mohapatra Bikram Keshari Kar Effect of daily teriparatide for delayed union of fracture neck of the femur Journal of Orthopedics, Traumatology and Rehabilitation delayed union neck of femur teriparatide |
| title | Effect of daily teriparatide for delayed union of fracture neck of the femur |
| title_full | Effect of daily teriparatide for delayed union of fracture neck of the femur |
| title_fullStr | Effect of daily teriparatide for delayed union of fracture neck of the femur |
| title_full_unstemmed | Effect of daily teriparatide for delayed union of fracture neck of the femur |
| title_short | Effect of daily teriparatide for delayed union of fracture neck of the femur |
| title_sort | effect of daily teriparatide for delayed union of fracture neck of the femur |
| topic | delayed union neck of femur teriparatide |
| url | http://www.jotr.in/article.asp?issn=0975-7341;year=2019;volume=11;issue=1;spage=49;epage=52;aulast=Mishra |
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