Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases
Hepatic angiomyolipoma is a rare neoplasm that can be difficult to diagnose in cases of ecoguide biopsy. We studied 4 cases of female patients with a mean age of 51 years. None of the patients presented specific abdominal symptoms, or other tumour masses detected by chance. One of them had relevant...
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| Format: | Article |
| Language: | English |
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Aran Ediciones
2016-01-01
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| Series: | Revista Espanola de Enfermedades Digestivas |
| Subjects: | |
| Online Access: | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000100006&lng=en&tlng=en |
| _version_ | 1819074656920928256 |
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| author | Santiago Ortiz Francisco Tortosa |
| author_facet | Santiago Ortiz Francisco Tortosa |
| author_sort | Santiago Ortiz |
| collection | DOAJ |
| description | Hepatic angiomyolipoma is a rare neoplasm that can be difficult to diagnose in cases of ecoguide biopsy. We studied 4 cases of female patients with a mean age of 51 years. None of the patients presented specific abdominal symptoms, or other tumour masses detected by chance. One of them had relevant personal history: Renal cell carcinoma. This same patient was diagnosed with a contralateral renal angiomyolipoma. None of the patients showed evidence of tuberous sclerosis. Three tumours have been diagnosed by biopsy and only in one patient was decided to completely remove the tumour surgically. None of the patients had evidence of recurrence of disease or an increase in tumour size over an average period of 45 months. Histologically, the tumours have been sub classified into angiomyolipomas epithelioid. In 50% of the cases, extramedullary haematopoiesis was observed. The first diagnostic impression using imaging methods included: Focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma and metastasis. By immunohistochemistry, it has been demonstrated that all tumours expressing melanocytic markers (HMB45 and Melan A) and markers of smooth muscle cells (smooth muscle actin). The diagnosis of these tumours is increasing due to programmes for early detection of hepatocellular carcinoma in patients with liver cirrhosis. It must be taken into account their broad spectrum of morphological diversity to avoid incorrect diagnosis of a malignant neoplasm. |
| first_indexed | 2024-12-21T18:12:59Z |
| format | Article |
| id | doaj.art-5580b2025f0e40a6acacb48d5ae622d8 |
| institution | Directory Open Access Journal |
| issn | 1130-0108 |
| language | English |
| last_indexed | 2024-12-21T18:12:59Z |
| publishDate | 2016-01-01 |
| publisher | Aran Ediciones |
| record_format | Article |
| series | Revista Espanola de Enfermedades Digestivas |
| spelling | doaj.art-5580b2025f0e40a6acacb48d5ae622d82022-12-21T18:54:44ZengAran EdicionesRevista Espanola de Enfermedades Digestivas1130-01082016-01-0110812730S1130-01082016000100006Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 casesSantiago Ortiz0Francisco Tortosa1Centro Hospitalar Lisboa NorteCentro Hospitalar Lisboa NorteHepatic angiomyolipoma is a rare neoplasm that can be difficult to diagnose in cases of ecoguide biopsy. We studied 4 cases of female patients with a mean age of 51 years. None of the patients presented specific abdominal symptoms, or other tumour masses detected by chance. One of them had relevant personal history: Renal cell carcinoma. This same patient was diagnosed with a contralateral renal angiomyolipoma. None of the patients showed evidence of tuberous sclerosis. Three tumours have been diagnosed by biopsy and only in one patient was decided to completely remove the tumour surgically. None of the patients had evidence of recurrence of disease or an increase in tumour size over an average period of 45 months. Histologically, the tumours have been sub classified into angiomyolipomas epithelioid. In 50% of the cases, extramedullary haematopoiesis was observed. The first diagnostic impression using imaging methods included: Focal nodular hyperplasia, hepatocellular adenoma, hepatocellular carcinoma and metastasis. By immunohistochemistry, it has been demonstrated that all tumours expressing melanocytic markers (HMB45 and Melan A) and markers of smooth muscle cells (smooth muscle actin). The diagnosis of these tumours is increasing due to programmes for early detection of hepatocellular carcinoma in patients with liver cirrhosis. It must be taken into account their broad spectrum of morphological diversity to avoid incorrect diagnosis of a malignant neoplasm.http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000100006&lng=en&tlng=enAngiomioliponaHígadoPEComa |
| spellingShingle | Santiago Ortiz Francisco Tortosa Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases Revista Espanola de Enfermedades Digestivas Angiomiolipona Hígado PEComa |
| title | Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases |
| title_full | Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases |
| title_fullStr | Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases |
| title_full_unstemmed | Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases |
| title_short | Epithelioid angiomyolipoma of the liver: clinicopathological correlation in a series of 4 cases |
| title_sort | epithelioid angiomyolipoma of the liver clinicopathological correlation in a series of 4 cases |
| topic | Angiomiolipona Hígado PEComa |
| url | http://scielo.isciii.es/scielo.php?script=sci_arttext&pid=S1130-01082016000100006&lng=en&tlng=en |
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