Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis
Abstract Background Vitamin D plays a crucial role in oral health, and its deficiency is associated to significant changes in oral health diseases. We aimed to explore the relationship between levels of 25-hydroxyvitamin D (25(OH) D) and dental caries in children. Methods Four electronic databases w...
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| Format: | Article |
| Language: | English |
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BMC
2023-10-01
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| Series: | BMC Oral Health |
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| Online Access: | https://doi.org/10.1186/s12903-023-03422-z |
| _version_ | 1797556019018072064 |
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| author | Zizhan Li Xiao Wei Zhongjun Shao Huan Liu Shizhu Bai |
| author_facet | Zizhan Li Xiao Wei Zhongjun Shao Huan Liu Shizhu Bai |
| author_sort | Zizhan Li |
| collection | DOAJ |
| description | Abstract Background Vitamin D plays a crucial role in oral health, and its deficiency is associated to significant changes in oral health diseases. We aimed to explore the relationship between levels of 25-hydroxyvitamin D (25(OH) D) and dental caries in children. Methods Four electronic databases were searched by two investigators including PubMed, Embase, Web of Science, and Cochrane Library. Dental caries results were presented as either prevalence or based on the index of primary and permanent teeth/surfaces with decaying, missing, and filled areas, while vitamin D levels were determined through laboratory testing. Two researchers independently selected studies, collected information, assessed risk of bias, and evaluated the study quality. Any disagreements were resolved through discussion. Results A total of 13 studies were included, comprising 5 cross-sectional studies, 5 cohort studies, 3 case–control studies, all of which had high methodological quality. Our meta-analysis showed that children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels, with a relative risk (RR) of 1.22 and a 95% confidence interval (CI) of 1.18 to 1. 25. Further subgroup analysis according to the three types of studies showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (cohort studies: 62%; cross-sectional studies, 19%; and case–control studies, 5%). Additionally, according to age, subgroup analysis also showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (permanent teeth studies, 28%; deciduous teeth studies, 68%; and mixed dentition studies 8%). Conclusions Levels of 25 (OH) D have been found negatively associated with dental caries in children, indicating that low vitamin D levels may be considered a potential risk factor to this dental disease. |
| first_indexed | 2024-03-10T16:55:46Z |
| format | Article |
| id | doaj.art-558102ab0a804806b4861b3b990f06f1 |
| institution | Directory Open Access Journal |
| issn | 1472-6831 |
| language | English |
| last_indexed | 2024-03-10T16:55:46Z |
| publishDate | 2023-10-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Oral Health |
| spelling | doaj.art-558102ab0a804806b4861b3b990f06f12023-11-20T11:07:32ZengBMCBMC Oral Health1472-68312023-10-0123111110.1186/s12903-023-03422-zCorrelation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysisZizhan Li0Xiao Wei1Zhongjun Shao2Huan Liu3Shizhu Bai4College of Basic Medical Sciences, Army Medical UniversityDepartment of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical UniversityDepartment of Epidemiology, Ministry of Education Key Lab of Hazard Assessment and Control in Special Operational Environment, School of Public Health, Air Force Medical UniversityDepartment of Stomatology, Xinqiao Hospital, Army Medical UniversityState Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, National Clinical Research Center for Oral Diseases, Shaanxi Key Laboratory of Stomatology, Digital Center of School of Stomatology, Air Force Medical UniversityAbstract Background Vitamin D plays a crucial role in oral health, and its deficiency is associated to significant changes in oral health diseases. We aimed to explore the relationship between levels of 25-hydroxyvitamin D (25(OH) D) and dental caries in children. Methods Four electronic databases were searched by two investigators including PubMed, Embase, Web of Science, and Cochrane Library. Dental caries results were presented as either prevalence or based on the index of primary and permanent teeth/surfaces with decaying, missing, and filled areas, while vitamin D levels were determined through laboratory testing. Two researchers independently selected studies, collected information, assessed risk of bias, and evaluated the study quality. Any disagreements were resolved through discussion. Results A total of 13 studies were included, comprising 5 cross-sectional studies, 5 cohort studies, 3 case–control studies, all of which had high methodological quality. Our meta-analysis showed that children with vitamin D deficiency had a 22% higher risk of dental caries than those with normal vitamin D levels, with a relative risk (RR) of 1.22 and a 95% confidence interval (CI) of 1.18 to 1. 25. Further subgroup analysis according to the three types of studies showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (cohort studies: 62%; cross-sectional studies, 19%; and case–control studies, 5%). Additionally, according to age, subgroup analysis also showed that the risk of dental caries in children with vitamin D deficiency was higher than that in normal vitamin D level group (permanent teeth studies, 28%; deciduous teeth studies, 68%; and mixed dentition studies 8%). Conclusions Levels of 25 (OH) D have been found negatively associated with dental caries in children, indicating that low vitamin D levels may be considered a potential risk factor to this dental disease.https://doi.org/10.1186/s12903-023-03422-zDental cariesVitamin DChildrenMeta-analysis |
| spellingShingle | Zizhan Li Xiao Wei Zhongjun Shao Huan Liu Shizhu Bai Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis BMC Oral Health Dental caries Vitamin D Children Meta-analysis |
| title | Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis |
| title_full | Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis |
| title_fullStr | Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis |
| title_full_unstemmed | Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis |
| title_short | Correlation between vitamin D levels in serum and the risk of dental caries in children: a systematic review and meta-analysis |
| title_sort | correlation between vitamin d levels in serum and the risk of dental caries in children a systematic review and meta analysis |
| topic | Dental caries Vitamin D Children Meta-analysis |
| url | https://doi.org/10.1186/s12903-023-03422-z |
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