From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts
Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches ai...
| Main Authors: | , , , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-09-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/14/18/3737 |
| _version_ | 1797483993492357120 |
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| author | Micaela Gliozzi Roberta Macrì Anna Rita Coppoletta Vincenzo Musolino Cristina Carresi Miriam Scicchitano Francesca Bosco Lorenza Guarnieri Antonio Cardamone Stefano Ruga Federica Scarano Saverio Nucera Rocco Mollace Irene Bava Rosamaria Caminiti Maria Serra Jessica Maiuolo Ernesto Palma Vincenzo Mollace |
| author_facet | Micaela Gliozzi Roberta Macrì Anna Rita Coppoletta Vincenzo Musolino Cristina Carresi Miriam Scicchitano Francesca Bosco Lorenza Guarnieri Antonio Cardamone Stefano Ruga Federica Scarano Saverio Nucera Rocco Mollace Irene Bava Rosamaria Caminiti Maria Serra Jessica Maiuolo Ernesto Palma Vincenzo Mollace |
| author_sort | Micaela Gliozzi |
| collection | DOAJ |
| description | Diabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients. |
| first_indexed | 2024-03-09T22:56:07Z |
| format | Article |
| id | doaj.art-558141873a16417082468debe70c0ec6 |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-09T22:56:07Z |
| publishDate | 2022-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-558141873a16417082468debe70c0ec62023-11-23T18:10:58ZengMDPI AGNutrients2072-66432022-09-011418373710.3390/nu14183737From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant ExtractsMicaela Gliozzi0Roberta Macrì1Anna Rita Coppoletta2Vincenzo Musolino3Cristina Carresi4Miriam Scicchitano5Francesca Bosco6Lorenza Guarnieri7Antonio Cardamone8Stefano Ruga9Federica Scarano10Saverio Nucera11Rocco Mollace12Irene Bava13Rosamaria Caminiti14Maria Serra15Jessica Maiuolo16Ernesto Palma17Vincenzo Mollace18Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmaceutical Biology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyVeterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmaceutical Biology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyVeterinary Pharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyPharmacology Laboratory, Institute of Research for Food Safety and Health IRC-FSH, Department of Health Sciences, University Magna Graecia of Catanzaro, 88100 Catanzaro, ItalyDiabetes is a complex chronic disease, and among the affected patients, cardiovascular disease (CVD)is the most common cause of death. Consequently, the evidence for the cardiovascular benefit of glycaemic control may reduce long-term CVD rates. Over the years, multiple pharmacological approaches aimed at controlling blood glucose levels were unable to significantly reduce diabetes-related cardiovascular events. In this view, a therapeutic strategy combining SGLT2 inhibitors and plant extracts might represent a promising solution. Indeed, countering the main cardiometabolic risk factor using plant extracts could potentiate the cardioprotective action of SGLT2 inhibitors. This review highlights the main molecular mechanisms underlying these beneficial effects that could contribute to the better management of diabetic patients.https://www.mdpi.com/2072-6643/14/18/3737diabetesinsulin resistancelipid accumulationinflammationreactive oxygen species (ROS)SGLT2 inhibitors |
| spellingShingle | Micaela Gliozzi Roberta Macrì Anna Rita Coppoletta Vincenzo Musolino Cristina Carresi Miriam Scicchitano Francesca Bosco Lorenza Guarnieri Antonio Cardamone Stefano Ruga Federica Scarano Saverio Nucera Rocco Mollace Irene Bava Rosamaria Caminiti Maria Serra Jessica Maiuolo Ernesto Palma Vincenzo Mollace From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts Nutrients diabetes insulin resistance lipid accumulation inflammation reactive oxygen species (ROS) SGLT2 inhibitors |
| title | From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts |
| title_full | From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts |
| title_fullStr | From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts |
| title_full_unstemmed | From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts |
| title_short | From Diabetes Care to Heart Failure Management: A Potential Therapeutic Approach Combining SGLT2 Inhibitors and Plant Extracts |
| title_sort | from diabetes care to heart failure management a potential therapeutic approach combining sglt2 inhibitors and plant extracts |
| topic | diabetes insulin resistance lipid accumulation inflammation reactive oxygen species (ROS) SGLT2 inhibitors |
| url | https://www.mdpi.com/2072-6643/14/18/3737 |
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