BmooMPα-I, a Metalloproteinase Isolated from <i>Bothrops moojeni</i> Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension

BmooMPα-I, a Metalloproteinase Isolated from <i>Bothrops moojeni</i> Venom, Reduces Blood Pressure, Reverses Left Ventricular Remodeling and Improves Cardiac Electrical Conduction in Rats with Renovascular Hypertension

BmooMPα-I has kininogenase activity, cleaving kininogen releasing bradykinin and can hydrolyze angiotensin I at post-proline and aspartic acid positions, generating an inactive peptide. We evaluated the antihypertensive activity of BmooMPα-I in a model of two-kidney, one-clip (2K1C). Wistar rats wer...

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Bibliographic Details
Main Authors: Jorge Eduardo Chang Estrada, Keuri Eleutério Rodrigues, Anderson Maciel, Cahy Manoel Bannwart, Wictória Farias Dias, Moisés Hamoy, Russolina Benedeta Zingali, Andreimar Martins Soares, Carolina Heitmann Mares Azevedo Ribeiro, Raquel Fernanda Gerlach, Marta Chagas Monteiro, Alejandro Ferraz Prado
Format: Article
Language:English
Published: MDPI AG 2022-11-01
Series:Toxins
Subjects:
cardioprotective effect
remodeling
fibrosis
snake venom
arrhythmia
Online Access:https://www.mdpi.com/2072-6651/14/11/766

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