Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis
The current study identifies five genomic subclusters of brain regions for cortical thickness and surface area characterized by high levels of shared genetic signal. These subclusters map onto biological and functional parcellations of the cortex.
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2023-02-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-023-36605-x |
| _version_ | 1797864210724552704 |
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| author | Andrew D. Grotzinger Travis T. Mallard Zhaowen Liu Jakob Seidlitz Tian Ge Jordan W. Smoller |
| author_facet | Andrew D. Grotzinger Travis T. Mallard Zhaowen Liu Jakob Seidlitz Tian Ge Jordan W. Smoller |
| author_sort | Andrew D. Grotzinger |
| collection | DOAJ |
| description | The current study identifies five genomic subclusters of brain regions for cortical thickness and surface area characterized by high levels of shared genetic signal. These subclusters map onto biological and functional parcellations of the cortex. |
| first_indexed | 2024-04-09T22:49:15Z |
| format | Article |
| id | doaj.art-558351e4e4a34c35ad3e76b038aa1876 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-09T22:49:15Z |
| publishDate | 2023-02-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-558351e4e4a34c35ad3e76b038aa18762023-03-22T11:42:28ZengNature PortfolioNature Communications2041-17232023-02-0114111310.1038/s41467-023-36605-xMultivariate genomic architecture of cortical thickness and surface area at multiple levels of analysisAndrew D. Grotzinger0Travis T. Mallard1Zhaowen Liu2Jakob Seidlitz3Tian Ge4Jordan W. Smoller5Institute for Behavioral Genetics, University of Colorado BoulderPsychiatric and Neurodevelopmental Genetics Unit, Massachusetts General HospitalPsychiatric and Neurodevelopmental Genetics Unit, Massachusetts General HospitalDepartment of Psychiatry, University of PennsylvaniaPsychiatric and Neurodevelopmental Genetics Unit, Massachusetts General HospitalPsychiatric and Neurodevelopmental Genetics Unit, Massachusetts General HospitalThe current study identifies five genomic subclusters of brain regions for cortical thickness and surface area characterized by high levels of shared genetic signal. These subclusters map onto biological and functional parcellations of the cortex.https://doi.org/10.1038/s41467-023-36605-x |
| spellingShingle | Andrew D. Grotzinger Travis T. Mallard Zhaowen Liu Jakob Seidlitz Tian Ge Jordan W. Smoller Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis Nature Communications |
| title | Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis |
| title_full | Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis |
| title_fullStr | Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis |
| title_full_unstemmed | Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis |
| title_short | Multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis |
| title_sort | multivariate genomic architecture of cortical thickness and surface area at multiple levels of analysis |
| url | https://doi.org/10.1038/s41467-023-36605-x |
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