Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus
The number of people with type 2 diabetes mellitus (T2DM) has increased sharply over the past decades. Apart from genetic predisposition, which may cause some of the diagnosed cases, an unhealthy diet and lifestyle are incentive triggers of this global epidemic. Consumption of probiotics and prebiot...
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| Format: | Article |
| Language: | English |
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MDPI AG
2022-08-01
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| Series: | Foods |
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| Online Access: | https://www.mdpi.com/2304-8158/11/16/2438 |
| _version_ | 1797410220324945920 |
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| author | Haoran Jiang Miaomiao Cai Boyuan Shen Qiong Wang Tongcun Zhang Xiang Zhou |
| author_facet | Haoran Jiang Miaomiao Cai Boyuan Shen Qiong Wang Tongcun Zhang Xiang Zhou |
| author_sort | Haoran Jiang |
| collection | DOAJ |
| description | The number of people with type 2 diabetes mellitus (T2DM) has increased sharply over the past decades. Apart from genetic predisposition, which may cause some of the diagnosed cases, an unhealthy diet and lifestyle are incentive triggers of this global epidemic. Consumption of probiotics and prebiotics to gain health benefits has become increasingly accepted by the public in recent years, and their critical roles in alleviating T2DM symptoms are confirmed by accumulating studies. Microbiome research reveals gut colonization by probiotics and their impacts on the host, while oral intake of prebiotics may stimulate existing metabolisms in the colon. The use of synbiotics (a combination of prebiotics and probiotics) can thus show a synergistic effect on T2DM through modulating the gastrointestinal microenvironment. This review summarizes the research progress in the treatment of T2DM from the perspective of synbiotics and gut microbiota and provides a class of synbiotics which are composed of lactulose, arabinose, and <i>Lactobacillus plantarum</i>, and can effectively adjust the blood glucose, blood lipid, and body weight of T2DM patients to ideal levels. |
| first_indexed | 2024-03-09T04:25:44Z |
| format | Article |
| id | doaj.art-558456c76324454f81fb0fdeb664fe64 |
| institution | Directory Open Access Journal |
| issn | 2304-8158 |
| language | English |
| last_indexed | 2024-03-09T04:25:44Z |
| publishDate | 2022-08-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Foods |
| spelling | doaj.art-558456c76324454f81fb0fdeb664fe642023-12-03T13:40:18ZengMDPI AGFoods2304-81582022-08-011116243810.3390/foods11162438Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes MellitusHaoran Jiang0Miaomiao Cai1Boyuan Shen2Qiong Wang3Tongcun Zhang4Xiang Zhou5College of Life Sciences & Health, Wuhan University of Science & Technology, Wuhan 430065, ChinaCollege of Life Sciences & Health, Wuhan University of Science & Technology, Wuhan 430065, ChinaCollege of Life Sciences & Health, Wuhan University of Science & Technology, Wuhan 430065, ChinaCollege of Life Sciences & Health, Wuhan University of Science & Technology, Wuhan 430065, ChinaCollege of Life Sciences & Health, Wuhan University of Science & Technology, Wuhan 430065, ChinaCollege of Life Sciences & Health, Wuhan University of Science & Technology, Wuhan 430065, ChinaThe number of people with type 2 diabetes mellitus (T2DM) has increased sharply over the past decades. Apart from genetic predisposition, which may cause some of the diagnosed cases, an unhealthy diet and lifestyle are incentive triggers of this global epidemic. Consumption of probiotics and prebiotics to gain health benefits has become increasingly accepted by the public in recent years, and their critical roles in alleviating T2DM symptoms are confirmed by accumulating studies. Microbiome research reveals gut colonization by probiotics and their impacts on the host, while oral intake of prebiotics may stimulate existing metabolisms in the colon. The use of synbiotics (a combination of prebiotics and probiotics) can thus show a synergistic effect on T2DM through modulating the gastrointestinal microenvironment. This review summarizes the research progress in the treatment of T2DM from the perspective of synbiotics and gut microbiota and provides a class of synbiotics which are composed of lactulose, arabinose, and <i>Lactobacillus plantarum</i>, and can effectively adjust the blood glucose, blood lipid, and body weight of T2DM patients to ideal levels.https://www.mdpi.com/2304-8158/11/16/2438synbioticsgut microbiotatype 2 diabetes mellitus<i>Lactobacillus plantarum</i> |
| spellingShingle | Haoran Jiang Miaomiao Cai Boyuan Shen Qiong Wang Tongcun Zhang Xiang Zhou Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus Foods synbiotics gut microbiota type 2 diabetes mellitus <i>Lactobacillus plantarum</i> |
| title | Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus |
| title_full | Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus |
| title_fullStr | Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus |
| title_full_unstemmed | Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus |
| title_short | Synbiotics and Gut Microbiota: New Perspectives in the Treatment of Type 2 Diabetes Mellitus |
| title_sort | synbiotics and gut microbiota new perspectives in the treatment of type 2 diabetes mellitus |
| topic | synbiotics gut microbiota type 2 diabetes mellitus <i>Lactobacillus plantarum</i> |
| url | https://www.mdpi.com/2304-8158/11/16/2438 |
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