GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

GIGYF1/2-Driven Cooperation between ZNF598 and TTP in Posttranscriptional Regulation of Inflammatory Signaling

Summary: Inflammatory signaling is restricted through degradation and the translational repression of cytokine mRNAs. A key factor in this regulation is tristetraprolin (TTP), an RNA-binding protein (RBP) that recruits RNA-destabilizing factors and the translation inhibitory complex 4EHP-GIGYF1/2 to...

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Main Authors: Maxim A.X. Tollenaere, Christopher Tiedje, Simon Rasmussen, Julie C. Nielsen, Anna C. Vind, Melanie Blasius, Tanveer S. Batth, Niels Mailand, Jesper V. Olsen, Matthias Gaestel, Simon Bekker-Jensen
Format: Article
Language:English
Published: Elsevier 2019-03-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124719303134

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