Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease.
BACKGROUND:Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicate...
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| Format: | Article |
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Public Library of Science (PLoS)
2018-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC5965884?pdf=render |
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| author | Chao Zhang Shuaiyin Chen Guangyuan Zhou Yuefei Jin Rongguang Zhang Haiyan Yang Yuanlin Xi Jingchao Ren Guangcai Duan |
| author_facet | Chao Zhang Shuaiyin Chen Guangyuan Zhou Yuefei Jin Rongguang Zhang Haiyan Yang Yuanlin Xi Jingchao Ren Guangcai Duan |
| author_sort | Chao Zhang |
| collection | DOAJ |
| description | BACKGROUND:Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD. METHODS:In the present study, 162 children including HFMD patients and healthy controls were recruited. The data was analyzed by time-series fashion. Concentrations of angiotensin II (Ang II) and noradrenaline (NA) in serum of patients were measured with ELISA. We established a mouse model for enterovirus 71 (EV71) infection and determined concentrations of Ang II, NA in tissue lysates at 3, 5 and 7 days post infection (dpi). RESULTS:The concentrations of Ang II and NA in serum of the HFMD patients with mild or severe symptoms were significantly higher than that in healthy controls. Additionally, the concentrations of Ang II and NA in serum of severe cases were significantly higher than those mild cases and the increased concentrations of Ang II and NA showed the same time trend during the progression of HFMD in the severe cases. Furthermore, the concentrations of Ang II and NA in target organs of EV71-infected mice including brains, skeletal muscle, and lungs were increased with the progression of EV71 infection in mice. Histopathological alterations were observed in the brains, skeletal muscle and lungs of EV71-infected mice. CONCLUSION:Our study suggested that activation of the RAS is implicated in the pathogenesis of severe HFMD. |
| first_indexed | 2024-04-13T21:56:22Z |
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| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-13T21:56:22Z |
| publishDate | 2018-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj.art-558adabc8c9045b088a297ec1c368f1c2022-12-22T02:28:15ZengPublic Library of Science (PLoS)PLoS ONE1932-62032018-01-01135e019786110.1371/journal.pone.0197861Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease.Chao ZhangShuaiyin ChenGuangyuan ZhouYuefei JinRongguang ZhangHaiyan YangYuanlin XiJingchao RenGuangcai DuanBACKGROUND:Hand-foot-and-mouth disease (HFMD) is generally considered as a mild exanthematous disease to infants and young children worldwide. HFMD cases are usually mild and self-limiting but for few cases leads to complicated severe clinical outcomes, and even death. Previous studies have indicated that serum Ang II levels in patients with H7N9 infection were related to the severity of infection. However, the mechanisms underlying the pathogenesis of severe HFMD remain unclear. This study was undertaken to clarify the role of the renin-angiotensin system (RAS) in the progression of severe HFMD. METHODS:In the present study, 162 children including HFMD patients and healthy controls were recruited. The data was analyzed by time-series fashion. Concentrations of angiotensin II (Ang II) and noradrenaline (NA) in serum of patients were measured with ELISA. We established a mouse model for enterovirus 71 (EV71) infection and determined concentrations of Ang II, NA in tissue lysates at 3, 5 and 7 days post infection (dpi). RESULTS:The concentrations of Ang II and NA in serum of the HFMD patients with mild or severe symptoms were significantly higher than that in healthy controls. Additionally, the concentrations of Ang II and NA in serum of severe cases were significantly higher than those mild cases and the increased concentrations of Ang II and NA showed the same time trend during the progression of HFMD in the severe cases. Furthermore, the concentrations of Ang II and NA in target organs of EV71-infected mice including brains, skeletal muscle, and lungs were increased with the progression of EV71 infection in mice. Histopathological alterations were observed in the brains, skeletal muscle and lungs of EV71-infected mice. CONCLUSION:Our study suggested that activation of the RAS is implicated in the pathogenesis of severe HFMD.http://europepmc.org/articles/PMC5965884?pdf=render |
| spellingShingle | Chao Zhang Shuaiyin Chen Guangyuan Zhou Yuefei Jin Rongguang Zhang Haiyan Yang Yuanlin Xi Jingchao Ren Guangcai Duan Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. PLoS ONE |
| title | Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. |
| title_full | Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. |
| title_fullStr | Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. |
| title_full_unstemmed | Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. |
| title_short | Involvement of the renin-angiotensin system in the progression of severe hand-foot-and-mouth disease. |
| title_sort | involvement of the renin angiotensin system in the progression of severe hand foot and mouth disease |
| url | http://europepmc.org/articles/PMC5965884?pdf=render |
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