Unravelling the landscape of skin cancer through single-cell transcriptomics
The human skin is a complex organ that forms the first line of defense against pathogens and external injury. It is composed of a wide variety of cells that work together to maintain homeostasis and prevent disease, such as skin cancer. The exponentially rising incidence of skin malignancies poses a...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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Elsevier
2023-01-01
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| Series: | Translational Oncology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S1936523322002169 |
| _version_ | 1811198108105703424 |
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| author | Ankit Srivastava Tomas Bencomo Ishani Das Carolyn S. Lee |
| author_facet | Ankit Srivastava Tomas Bencomo Ishani Das Carolyn S. Lee |
| author_sort | Ankit Srivastava |
| collection | DOAJ |
| description | The human skin is a complex organ that forms the first line of defense against pathogens and external injury. It is composed of a wide variety of cells that work together to maintain homeostasis and prevent disease, such as skin cancer. The exponentially rising incidence of skin malignancies poses a growing public health challenge, particularly when the disease course is complicated by metastasis and therapeutic resistance. Recent advances in single-cell transcriptomics have provided a high-resolution view of gene expression heterogeneity that can be applied to skin cancers to define cell types and states, understand disease evolution, and develop new therapeutic concepts. This approach has been particularly valuable in characterizing the contribution of immune cells in skin cancer, an area of great clinical importance given the increasing use of immunotherapy in this setting. In this review, we highlight recent skin cancer studies utilizing bulk RNA sequencing, introduce various single-cell transcriptomics approaches, and summarize key findings obtained by applying single-cell transcriptomics to skin cancer. |
| first_indexed | 2024-04-12T01:25:20Z |
| format | Article |
| id | doaj.art-558b1494b5d24d258567f414485cd7eb |
| institution | Directory Open Access Journal |
| issn | 1936-5233 |
| language | English |
| last_indexed | 2024-04-12T01:25:20Z |
| publishDate | 2023-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Translational Oncology |
| spelling | doaj.art-558b1494b5d24d258567f414485cd7eb2022-12-22T03:53:40ZengElsevierTranslational Oncology1936-52332023-01-0127101557Unravelling the landscape of skin cancer through single-cell transcriptomicsAnkit Srivastava0Tomas Bencomo1Ishani Das2Carolyn S. Lee3Stanford Program in Epithelial Biology, Stanford University, Stanford, CA 94305 United States of America; Department of Microbiology, Tumor and Cell Biology, Science for Life Laboratory, Karolinska Institute, Stockholm 17177, SwedenStanford Program in Epithelial Biology, Stanford University, Stanford, CA 94305 United States of AmericaDivision of Oncology, School of Medicine, Stanford University, Stanford, CA 94305 United States of AmericaStanford Program in Epithelial Biology, Stanford University, Stanford, CA 94305 United States of America; Stanford Cancer Institute, Stanford University, Stanford, CA 94305 United States of America; Veterans Affairs Palo Alto Healthcare System, Palo Alto, CA 94304 United States of America; Corresponding author at: 269 Campus Drive, Room 2160, Stanford, CA 94305.The human skin is a complex organ that forms the first line of defense against pathogens and external injury. It is composed of a wide variety of cells that work together to maintain homeostasis and prevent disease, such as skin cancer. The exponentially rising incidence of skin malignancies poses a growing public health challenge, particularly when the disease course is complicated by metastasis and therapeutic resistance. Recent advances in single-cell transcriptomics have provided a high-resolution view of gene expression heterogeneity that can be applied to skin cancers to define cell types and states, understand disease evolution, and develop new therapeutic concepts. This approach has been particularly valuable in characterizing the contribution of immune cells in skin cancer, an area of great clinical importance given the increasing use of immunotherapy in this setting. In this review, we highlight recent skin cancer studies utilizing bulk RNA sequencing, introduce various single-cell transcriptomics approaches, and summarize key findings obtained by applying single-cell transcriptomics to skin cancer.http://www.sciencedirect.com/science/article/pii/S1936523322002169SkinSingle-cell transcriptomicsSingle-cell RNA-sequencingSpatial transcriptomicsMelanomaBasal cell carcinoma |
| spellingShingle | Ankit Srivastava Tomas Bencomo Ishani Das Carolyn S. Lee Unravelling the landscape of skin cancer through single-cell transcriptomics Translational Oncology Skin Single-cell transcriptomics Single-cell RNA-sequencing Spatial transcriptomics Melanoma Basal cell carcinoma |
| title | Unravelling the landscape of skin cancer through single-cell transcriptomics |
| title_full | Unravelling the landscape of skin cancer through single-cell transcriptomics |
| title_fullStr | Unravelling the landscape of skin cancer through single-cell transcriptomics |
| title_full_unstemmed | Unravelling the landscape of skin cancer through single-cell transcriptomics |
| title_short | Unravelling the landscape of skin cancer through single-cell transcriptomics |
| title_sort | unravelling the landscape of skin cancer through single cell transcriptomics |
| topic | Skin Single-cell transcriptomics Single-cell RNA-sequencing Spatial transcriptomics Melanoma Basal cell carcinoma |
| url | http://www.sciencedirect.com/science/article/pii/S1936523322002169 |
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