Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

Targeting Cytosolic Nucleic Acid-Sensing Pathways for Cancer Immunotherapies

The innate immune system provides the first line of defense against pathogen infection though also influences pathways involved in cancer immunosurveillance. The innate immune system relies on a limited set of germ line-encoded sensors termed pattern recognition receptors (PRRs), signaling proteins...

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Bibliographic Details
Main Authors: Sandra Iurescia, Daniela Fioretti, Monica Rinaldi
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Immunology
Subjects:
DAMPs
STING
RIG-1
innate immune system
cytosolic nucleic acid receptors
antitumor response
Online Access:http://journal.frontiersin.org/article/10.3389/fimmu.2018.00711/full

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