GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation

GFI1B and LSD1 repress myeloid traits during megakaryocyte differentiation

Abstract The transcription factor Growth Factor Independence 1B (GFI1B) recruits Lysine Specific Demethylase 1 A (LSD1/KDM1A) to stimulate gene programs relevant for megakaryocyte and platelet biology. Inherited pathogenic GFI1B variants result in thrombocytopenia and bleeding propensities with vary...

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Main Authors: Jeron Venhuizen, Maaike G. J. M. van Bergen, Saskia M. Bergevoet, Daan Gilissen, Cornelia G. Spruijt, Laura Wingens, Emile van den Akker, Michiel Vermeulen, Joop H. Jansen, Joost H. A. Martens, Bert A. van der Reijden
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Communications Biology
Online Access:https://doi.org/10.1038/s42003-024-06090-z

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