An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity
The aim of this study was to investigate the effect of different novel extracts and fractions obtained from Allium sativum (garlic) on in vitro vessel contraction in order to deepen our knowledge of their mechanism of action on vascular reactivity. The contraction induced by noradrenaline (NE, 10-6...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2004-01-01
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| Series: | Journal of Pharmacological Sciences |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S134786131932479X |
| _version_ | 1818159669886058496 |
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| author | Patricia Ganado Mercedes Sanz Eugenia Padilla Teresa Tejerina |
| author_facet | Patricia Ganado Mercedes Sanz Eugenia Padilla Teresa Tejerina |
| author_sort | Patricia Ganado |
| collection | DOAJ |
| description | The aim of this study was to investigate the effect of different novel extracts and fractions obtained from Allium sativum (garlic) on in vitro vessel contraction in order to deepen our knowledge of their mechanism of action on vascular reactivity. The contraction induced by noradrenaline (NE, 10-6 or 10-5 M) or KCl (80 mM) was relaxed with all the extracts and fractions studied, but this effect was higher with RG 20-100 (raw garlic fraction) and FG 20-100 (frozen garlic fraction). To increase our understanding of the mechanisms of action of RG 200-100 and FG 200-100, we found their inhibitory actions were retained in the absence of endothelium, whereas inhibition of the entry of extracellular calcium and mobilization of intracellular calcium may play an instrumental role. Keywords:: Allium sativum (garlic), vascular reactivity, aorta, mesenteric artery (4th branch) |
| first_indexed | 2024-12-11T15:49:40Z |
| format | Article |
| id | doaj.art-558ff56ad3ab4b188bfa6ac0c98ae8c1 |
| institution | Directory Open Access Journal |
| issn | 1347-8613 |
| language | English |
| last_indexed | 2024-12-11T15:49:40Z |
| publishDate | 2004-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Journal of Pharmacological Sciences |
| spelling | doaj.art-558ff56ad3ab4b188bfa6ac0c98ae8c12022-12-22T00:59:36ZengElsevierJournal of Pharmacological Sciences1347-86132004-01-01944434442An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular ReactivityPatricia Ganado0Mercedes Sanz1Eugenia Padilla2Teresa Tejerina3Department of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, SpainDepartment of Pharmacology, School of Medicine, Universidad Complutense de Madrid, 28040 Madrid, Spain; Corresponding author. FAX: +34-91-394-1476 E-mail: teje@med.ucm.esThe aim of this study was to investigate the effect of different novel extracts and fractions obtained from Allium sativum (garlic) on in vitro vessel contraction in order to deepen our knowledge of their mechanism of action on vascular reactivity. The contraction induced by noradrenaline (NE, 10-6 or 10-5 M) or KCl (80 mM) was relaxed with all the extracts and fractions studied, but this effect was higher with RG 20-100 (raw garlic fraction) and FG 20-100 (frozen garlic fraction). To increase our understanding of the mechanisms of action of RG 200-100 and FG 200-100, we found their inhibitory actions were retained in the absence of endothelium, whereas inhibition of the entry of extracellular calcium and mobilization of intracellular calcium may play an instrumental role. Keywords:: Allium sativum (garlic), vascular reactivity, aorta, mesenteric artery (4th branch)http://www.sciencedirect.com/science/article/pii/S134786131932479X |
| spellingShingle | Patricia Ganado Mercedes Sanz Eugenia Padilla Teresa Tejerina An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity Journal of Pharmacological Sciences |
| title | An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity |
| title_full | An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity |
| title_fullStr | An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity |
| title_full_unstemmed | An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity |
| title_short | An In Vitro Study of Different Extracts and Fractions of Allium sativum (Garlic): Vascular Reactivity |
| title_sort | in vitro study of different extracts and fractions of allium sativum garlic vascular reactivity |
| url | http://www.sciencedirect.com/science/article/pii/S134786131932479X |
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