Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis
Abstract Background Congenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 year...
| Main Authors: | , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2023-01-01
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| Series: | Cost Effectiveness and Resource Allocation |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12962-022-00411-x |
| _version_ | 1828051719111573504 |
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| author | Anna-Janina Stephan Marion de Lepper Regine Wölle Agnes Luzak Wei Wang Christian Jacob Kim Maren Schneider Horst Buxmann Rangmar Goelz Klaus Hamprecht Peter Kummer Susanne Modrow Wolfgang Greiner Miriam Reuschenbach |
| author_facet | Anna-Janina Stephan Marion de Lepper Regine Wölle Agnes Luzak Wei Wang Christian Jacob Kim Maren Schneider Horst Buxmann Rangmar Goelz Klaus Hamprecht Peter Kummer Susanne Modrow Wolfgang Greiner Miriam Reuschenbach |
| author_sort | Anna-Janina Stephan |
| collection | DOAJ |
| description | Abstract Background Congenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life. Methods We conducted a retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database. Incremental healthcare costs during the first and second year of life were assessed by matching (1:60) infants with cCMV diagnoses ≤ 90 days after birth (cCMV90 cohort) to infants without cCMV diagnosis (“representative” controls) and infants with cCMV diagnoses ≤ 21 days after birth plus specific symptoms (cCMV21-S) to infants without cCMV and any ICD-10-GM records (besides Z00-Z99) until 4th preventive health check-up (“healthy” controls). Due to missing data, mean imputation was applied for aids and remedies costs. Results We identified 54 and 24 infants born 2014–2018 for the cCMV90 and cCMV21-S cohorts, respectively. During the first year, mean (median) healthcare costs were significantly higher in cCMV90 cases vs. “representative” controls (€22,737 (€9759) vs. €3091 (€863), p < 0.001), with 87.2% inpatient costs. Healthcare costs for cCMV21-S cases compared to “healthy” controls were €34,498 (€20,924) vs. €680 (€569), p < 0.001. Differences decreased for both comparisons in the second year but remained statistically significant. Conclusions cCMV comprises a considerable economic burden for the German healthcare system (€19,646 to €33,818 higher mean costs for infants with recorded cCMV diagnosis in the first year of life). Attempts should be made to reduce this burden. |
| first_indexed | 2024-04-10T19:43:00Z |
| format | Article |
| id | doaj.art-55901e2152b1418ea263d291893cedf3 |
| institution | Directory Open Access Journal |
| issn | 1478-7547 |
| language | English |
| last_indexed | 2024-04-10T19:43:00Z |
| publishDate | 2023-01-01 |
| publisher | BMC |
| record_format | Article |
| series | Cost Effectiveness and Resource Allocation |
| spelling | doaj.art-55901e2152b1418ea263d291893cedf32023-01-29T12:13:28ZengBMCCost Effectiveness and Resource Allocation1478-75472023-01-0121111210.1186/s12962-022-00411-xHealthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysisAnna-Janina Stephan0Marion de Lepper1Regine Wölle2Agnes Luzak3Wei Wang4Christian Jacob5Kim Maren Schneider6Horst Buxmann7Rangmar Goelz8Klaus Hamprecht9Peter Kummer10Susanne Modrow11Wolfgang Greiner12Miriam Reuschenbach13Department of Market Access, MSD Sharp & Dohme GmbHDepartment of Medical Affairs, MSD Sharp & Dohme GmbHDepartment of Market Access, MSD Sharp & Dohme GmbHDepartment of Market Access, MSD Sharp & Dohme GmbHCenter for Observational and Real-World Evidence (CORE), Merck & Co., Inc.EU Real World Evidence, Xcenda GmbHEU Real World Evidence, Xcenda GmbHDepartment for Children and Adolescents, Division for Neonatology, Main-Kinzig-Kliniken GmbHDepartment of Neonatology, University Children’s HospitalInstitute for Medical Virology and Epidemiology of Viral Diseases, University of TuebingenSection of Phoniatrics and Pediatric Audiology, Department of Otolaryngology, University Hospital RegensburgInstitute of Medical Microbiology and Hygiene, University Hospital RegensburgDepartment of Health Economics and Health Care Management, Bielefeld School of Public Health, Bielefeld UniversityGlobal Medical and Scientific Affairs, MSD Sharp & Dohme GmbHAbstract Background Congenital cytomegalovirus (cCMV) infection can cause severe neurological damage, growth retardation, hearing loss, and microcephaly in infants. We aimed at assessing healthcare costs of infants with recorded cCMV diagnosis in an administrative claims database in the first 2 years of life. Methods We conducted a retrospective, controlled cohort study using German claims data from the Institute for Applied Health Research Berlin (InGef) database. Incremental healthcare costs during the first and second year of life were assessed by matching (1:60) infants with cCMV diagnoses ≤ 90 days after birth (cCMV90 cohort) to infants without cCMV diagnosis (“representative” controls) and infants with cCMV diagnoses ≤ 21 days after birth plus specific symptoms (cCMV21-S) to infants without cCMV and any ICD-10-GM records (besides Z00-Z99) until 4th preventive health check-up (“healthy” controls). Due to missing data, mean imputation was applied for aids and remedies costs. Results We identified 54 and 24 infants born 2014–2018 for the cCMV90 and cCMV21-S cohorts, respectively. During the first year, mean (median) healthcare costs were significantly higher in cCMV90 cases vs. “representative” controls (€22,737 (€9759) vs. €3091 (€863), p < 0.001), with 87.2% inpatient costs. Healthcare costs for cCMV21-S cases compared to “healthy” controls were €34,498 (€20,924) vs. €680 (€569), p < 0.001. Differences decreased for both comparisons in the second year but remained statistically significant. Conclusions cCMV comprises a considerable economic burden for the German healthcare system (€19,646 to €33,818 higher mean costs for infants with recorded cCMV diagnosis in the first year of life). Attempts should be made to reduce this burden.https://doi.org/10.1186/s12962-022-00411-xCongenital CMV infectionNewbornsHealth economic burdenGermanyAdministrative data |
| spellingShingle | Anna-Janina Stephan Marion de Lepper Regine Wölle Agnes Luzak Wei Wang Christian Jacob Kim Maren Schneider Horst Buxmann Rangmar Goelz Klaus Hamprecht Peter Kummer Susanne Modrow Wolfgang Greiner Miriam Reuschenbach Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis Cost Effectiveness and Resource Allocation Congenital CMV infection Newborns Health economic burden Germany Administrative data |
| title | Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis |
| title_full | Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis |
| title_fullStr | Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis |
| title_full_unstemmed | Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis |
| title_short | Healthcare costs of congenital cytomegalovirus (cCMV) disease in infants during the first two years of life: a retrospective German claims database analysis |
| title_sort | healthcare costs of congenital cytomegalovirus ccmv disease in infants during the first two years of life a retrospective german claims database analysis |
| topic | Congenital CMV infection Newborns Health economic burden Germany Administrative data |
| url | https://doi.org/10.1186/s12962-022-00411-x |
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