USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS
Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of in...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2021-05-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-021-23219-4 |
| _version_ | 1818682464680280064 |
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| author | Jinxiu Hou Lulu Han Ze Zhao Huiqing Liu Lei Zhang Chunhong Ma Fan Yi Bingyu Liu Yi Zheng Chengjiang Gao |
| author_facet | Jinxiu Hou Lulu Han Ze Zhao Huiqing Liu Lei Zhang Chunhong Ma Fan Yi Bingyu Liu Yi Zheng Chengjiang Gao |
| author_sort | Jinxiu Hou |
| collection | DOAJ |
| description | Ubiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of interaction between MAVS and TRIM31. |
| first_indexed | 2024-12-17T10:19:16Z |
| format | Article |
| id | doaj.art-55913ebdaee8461bb5eb2e3bfac8cd04 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-12-17T10:19:16Z |
| publishDate | 2021-05-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-55913ebdaee8461bb5eb2e3bfac8cd042022-12-21T21:52:50ZengNature PortfolioNature Communications2041-17232021-05-0112111610.1038/s41467-021-23219-4USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVSJinxiu Hou0Lulu Han1Ze Zhao2Huiqing Liu3Lei Zhang4Chunhong Ma5Fan Yi6Bingyu Liu7Yi Zheng8Chengjiang Gao9Key Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityKey Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityDepartment of Pharmacology, School of Basic Medical Sciences, Shandong UniversityDepartment of Pharmacology, School of Basic Medical Sciences, Shandong UniversityKey Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityKey Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityDepartment of Pharmacology, School of Basic Medical Sciences, Shandong UniversityKey Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityKey Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityKey Laboratory of Infection and Immunity of Shandong Province & Department of Immunology, School of Basic Medical Sciences, Shandong UniversityUbiquitination has an important function in the regulation of antiviral immunity involving the signalling molecule MAVS. Here the authors investigate deubiquitinating enzymes and show USP18 regulates MAVS mediated antiviral signalling through modulating the ubiquitination of MAVS via promotion of interaction between MAVS and TRIM31.https://doi.org/10.1038/s41467-021-23219-4 |
| spellingShingle | Jinxiu Hou Lulu Han Ze Zhao Huiqing Liu Lei Zhang Chunhong Ma Fan Yi Bingyu Liu Yi Zheng Chengjiang Gao USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS Nature Communications |
| title | USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS |
| title_full | USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS |
| title_fullStr | USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS |
| title_full_unstemmed | USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS |
| title_short | USP18 positively regulates innate antiviral immunity by promoting K63-linked polyubiquitination of MAVS |
| title_sort | usp18 positively regulates innate antiviral immunity by promoting k63 linked polyubiquitination of mavs |
| url | https://doi.org/10.1038/s41467-021-23219-4 |
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