Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review
Epilepsy is a chronic brain disorder that causes repeated seizures. It affects 65 million people worldwide and is a major burden on individuals and health systems. It has been reported that factors leading to ion channel disfuntion, neuronal damage and are all involved in the pathogenesis of epileps...
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| Format: | Article |
| Language: | English |
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IMR Press
2022-05-01
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| Series: | Journal of Integrative Neuroscience |
| Subjects: | |
| Online Access: | https://www.imrpress.com/journal/JIN/21/4/10.31083/j.jin2104102 |
| _version_ | 1828260788917239808 |
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| author | Peng Chen Fuchao Chen Benhong Zhou |
| author_facet | Peng Chen Fuchao Chen Benhong Zhou |
| author_sort | Peng Chen |
| collection | DOAJ |
| description | Epilepsy is a chronic brain disorder that causes repeated seizures. It affects 65 million people worldwide and is a major burden on individuals and health systems. It has been reported that factors leading to ion channel disfuntion, neuronal damage and are all involved in the pathogenesis of epilepsy. The exact etipathogenic mechanism is unknown and appropriate therapeutic targets remain elusive. Recent studies point to a significant contribution by non-neuronal cells, the glia—especially astrocytes and microglia—in the pathophysiology of epilepsy. This review critically evaluates the role of glia-induced hyperexcitability in the pathogenesis of epilepsy to provide a better understanding of the contribution of glia to epilepsy. |
| first_indexed | 2024-04-13T03:28:20Z |
| format | Article |
| id | doaj.art-5591e621c367423081879058de2a4a45 |
| institution | Directory Open Access Journal |
| issn | 0219-6352 |
| language | English |
| last_indexed | 2024-04-13T03:28:20Z |
| publishDate | 2022-05-01 |
| publisher | IMR Press |
| record_format | Article |
| series | Journal of Integrative Neuroscience |
| spelling | doaj.art-5591e621c367423081879058de2a4a452022-12-22T03:04:34ZengIMR PressJournal of Integrative Neuroscience0219-63522022-05-0121410210.31083/j.jin2104102S0219-6352(22)00379-5Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A ReviewPeng Chen0Fuchao Chen1Benhong Zhou2Department of Pharmacy, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, ChinaDepartment of Pharmacy, Sinopharm Dongfeng General Hospital, Hubei University of Medicine, 442099 Shiyan, Hubei, ChinaDepartment of Pharmacy, Renmin Hospital of Wuhan University, 430060 Wuhan, Hubei, ChinaEpilepsy is a chronic brain disorder that causes repeated seizures. It affects 65 million people worldwide and is a major burden on individuals and health systems. It has been reported that factors leading to ion channel disfuntion, neuronal damage and are all involved in the pathogenesis of epilepsy. The exact etipathogenic mechanism is unknown and appropriate therapeutic targets remain elusive. Recent studies point to a significant contribution by non-neuronal cells, the glia—especially astrocytes and microglia—in the pathophysiology of epilepsy. This review critically evaluates the role of glia-induced hyperexcitability in the pathogenesis of epilepsy to provide a better understanding of the contribution of glia to epilepsy.https://www.imrpress.com/journal/JIN/21/4/10.31083/j.jin2104102glianeuroninteractionsepilepsypathophysiology |
| spellingShingle | Peng Chen Fuchao Chen Benhong Zhou Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review Journal of Integrative Neuroscience glia neuron interactions epilepsy pathophysiology |
| title | Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review |
| title_full | Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review |
| title_fullStr | Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review |
| title_full_unstemmed | Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review |
| title_short | Understanding the Role of Glia-Neuron Communication in the Pathophysiology of Epilepsy: A Review |
| title_sort | understanding the role of glia neuron communication in the pathophysiology of epilepsy a review |
| topic | glia neuron interactions epilepsy pathophysiology |
| url | https://www.imrpress.com/journal/JIN/21/4/10.31083/j.jin2104102 |
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