SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation

SYNCRIP facilitates porcine parvovirus viral DNA replication through the alternative splicing of NS1 mRNA to promote NS2 mRNA formation

Abstract Porcine Parvovirus (PPV), a pathogen causing porcine reproductive disorders, encodes two capsid proteins (VP1 and VP2) and three nonstructural proteins (NS1, NS2 and SAT) in infected cells. The PPV NS2 mRNA is from NS1 mRNA after alternative splicing, yet the corresponding mechanism is uncl...

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Bibliographic Details
Main Authors: Songbiao Chen, Bichen Miao, Nannan Chen, Caiyi Chen, Ting Shao, Xuezhi Zhang, Lingling Chang, Xiujuan Zhang, Qian Du, Yong Huang, Dewen Tong
Format: Article
Language:English
Published: BMC 2021-05-01
Series:Veterinary Research
Subjects:
PPV
SYNCRIP
NS1 mRNA
Alternative splicing
NS2 mRNA
Online Access:https://doi.org/10.1186/s13567-021-00938-6

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