Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR
<p>Abstract</p> <p>Background</p> <p>Accumulating evidence reveals that intrauterine growth retardation (IUGR) can cause varying degrees of pulmonary arterial hypertension (PAH) later in life. Moreover, epigenetics plays an important role in the fetal origin of adult di...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2013-02-01
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| Series: | Respiratory Research |
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| Online Access: | http://respiratory-research.com/content/14/1/20 |
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| author | Xu Xue-Feng Lv Ying Gu Wei-Zhong Tang Li-Li Wei Jia-Kai Zhang Li-Yan Du Li-Zhong |
| author_facet | Xu Xue-Feng Lv Ying Gu Wei-Zhong Tang Li-Li Wei Jia-Kai Zhang Li-Yan Du Li-Zhong |
| author_sort | Xu Xue-Feng |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Background</p> <p>Accumulating evidence reveals that intrauterine growth retardation (IUGR) can cause varying degrees of pulmonary arterial hypertension (PAH) later in life. Moreover, epigenetics plays an important role in the fetal origin of adult disease. The goal of this study was to investigate the role of epigenetics in the development of PAH following IUGR.</p> <p>Methods</p> <p>The IUGR rats were established by maternal undernutrition during pregnancy. Pulmonary vascular endothelial cells (PVEC) were isolated from the rat lungs by magnetic-activated cell sorting (MACS). We investigated epigenetic regulation of the endothelin-1 (ET-1) gene in PVEC of 1-day and 6-week IUGR rats, and response of IUGR rats to hypoxia.</p> <p>Results</p> <p>The maternal nutrient restriction increased the histone acetylation and hypoxia inducible factor-1α (HIF-1α) binding levels in the ET-1 gene promoter of PVEC in IUGR newborn rats, and continued up to 6 weeks after birth. These epigenetic changes could result in an IUGR rat being highly sensitive to hypoxia later in life, causing more significant PAH or pulmonary vascular remodeling.</p> <p>Conclusions</p> <p>These findings suggest that epigenetics is closely associated with the development of hypoxic PAH following IUGR, further providing a new insight for improved prevention and treatment of IUGR-related PAH.</p> |
| first_indexed | 2024-12-18T05:54:09Z |
| format | Article |
| id | doaj.art-55955f6e2c324a2c8868ca4c2b940dce |
| institution | Directory Open Access Journal |
| issn | 1465-9921 |
| language | English |
| last_indexed | 2024-12-18T05:54:09Z |
| publishDate | 2013-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Respiratory Research |
| spelling | doaj.art-55955f6e2c324a2c8868ca4c2b940dce2022-12-21T21:18:51ZengBMCRespiratory Research1465-99212013-02-011412010.1186/1465-9921-14-20Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGRXu Xue-FengLv YingGu Wei-ZhongTang Li-LiWei Jia-KaiZhang Li-YanDu Li-Zhong<p>Abstract</p> <p>Background</p> <p>Accumulating evidence reveals that intrauterine growth retardation (IUGR) can cause varying degrees of pulmonary arterial hypertension (PAH) later in life. Moreover, epigenetics plays an important role in the fetal origin of adult disease. The goal of this study was to investigate the role of epigenetics in the development of PAH following IUGR.</p> <p>Methods</p> <p>The IUGR rats were established by maternal undernutrition during pregnancy. Pulmonary vascular endothelial cells (PVEC) were isolated from the rat lungs by magnetic-activated cell sorting (MACS). We investigated epigenetic regulation of the endothelin-1 (ET-1) gene in PVEC of 1-day and 6-week IUGR rats, and response of IUGR rats to hypoxia.</p> <p>Results</p> <p>The maternal nutrient restriction increased the histone acetylation and hypoxia inducible factor-1α (HIF-1α) binding levels in the ET-1 gene promoter of PVEC in IUGR newborn rats, and continued up to 6 weeks after birth. These epigenetic changes could result in an IUGR rat being highly sensitive to hypoxia later in life, causing more significant PAH or pulmonary vascular remodeling.</p> <p>Conclusions</p> <p>These findings suggest that epigenetics is closely associated with the development of hypoxic PAH following IUGR, further providing a new insight for improved prevention and treatment of IUGR-related PAH.</p>http://respiratory-research.com/content/14/1/20EpigeneticsPulmonary arterial hypertensionEndothelial cellsEndothelin-1Intrauterine growth retardation |
| spellingShingle | Xu Xue-Feng Lv Ying Gu Wei-Zhong Tang Li-Li Wei Jia-Kai Zhang Li-Yan Du Li-Zhong Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR Respiratory Research Epigenetics Pulmonary arterial hypertension Endothelial cells Endothelin-1 Intrauterine growth retardation |
| title | Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR |
| title_full | Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR |
| title_fullStr | Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR |
| title_full_unstemmed | Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR |
| title_short | Epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat: epigenetics in PAH following IUGR |
| title_sort | epigenetics of hypoxic pulmonary arterial hypertension following intrauterine growth retardation rat epigenetics in pah following iugr |
| topic | Epigenetics Pulmonary arterial hypertension Endothelial cells Endothelin-1 Intrauterine growth retardation |
| url | http://respiratory-research.com/content/14/1/20 |
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