Survival analysis of postoperative recurrence of meningioma: 176 cases report
Objective To investigate the influencing factors of postoperative meningioma recurrence. Methods A total of 176 patients with meningioma treated in Beijing Tiantan Hospital, Capital Medical University from May 2010 to January 2011 were included. The general information, imaging findings, extent of t...
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| Format: | Article |
| Language: | English |
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Tianjin Huanhu Hospital
2022-11-01
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| Series: | Chinese Journal of Contemporary Neurology and Neurosurgery |
| Subjects: | |
| Online Access: | http://www.cjcnn.org/index.php/cjcnn/article/view/2594 |
| _version_ | 1811294371634479104 |
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| author | HUANG Guan⁃you HAO Shu⁃yu WANG Liang ZHANG Li⁃wei ZHANG Jun⁃ting WU Zhen |
| author_facet | HUANG Guan⁃you HAO Shu⁃yu WANG Liang ZHANG Li⁃wei ZHANG Jun⁃ting WU Zhen |
| author_sort | HUANG Guan⁃you |
| collection | DOAJ |
| description | Objective To investigate the influencing factors of postoperative meningioma recurrence. Methods A total of 176 patients with meningioma treated in Beijing Tiantan Hospital, Capital Medical University from May 2010 to January 2011 were included. The general information, imaging findings, extent of tumor resection and postoperative pathological results were analyzed. Kaplan⁃Meier survival curve comparison and Log⁃rank test were used to compare the related influencing factors of meningioma recurrence. Multifactor Cox's proportional hazards regression model was used for survival analysis. Results The median progression free survival (PFS) of patients with preoperative Karnofsky Performance Status (KPS)＜70 was lower than that with KPS≥70 [(8.04±1.98) years vs. (8.08±1.18) years; χ2=5.370, P=0.020]. The median PFS of patients with peritumoral edema grade 2-3 was lower than that with peritumoral edema grade 0-1 [(8.05±1.79) years vs. (8.06±1.09) years; χ2=9.805, P=0.002]. The median PFS of patients with dural mater invasion was lower than that without dural mater invasion [(7.97±1.70) years vs. (8.06±1.09) years; χ2=12.357, P=0.000]. The median PFS of patients with WHO grade 2-3 was lower than that with WHO grade 1 [(5.14±2.07) years vs. (8.12±0.87) years; χ2=113.774, P=0.000]. Multivariate Cox's proportional hazards regression model showed that WHO grade 2-3 could increase the risk of postoperative meningioma recurrence (RR=15.693, 95%CI: 5.905-41.707; P=0.000). Conclusions The preoperative KPS score, peritumoral edema, dura mater invasion and WHO grade may affect the recurrence of meningioma, and WHO grade 2-3 can increase the risk of meningioma recurrence. |
| first_indexed | 2024-04-13T05:16:31Z |
| format | Article |
| id | doaj.art-5595982ba1634d0a96469fb57d7d176b |
| institution | Directory Open Access Journal |
| issn | 1672-6731 |
| language | English |
| last_indexed | 2024-04-13T05:16:31Z |
| publishDate | 2022-11-01 |
| publisher | Tianjin Huanhu Hospital |
| record_format | Article |
| series | Chinese Journal of Contemporary Neurology and Neurosurgery |
| spelling | doaj.art-5595982ba1634d0a96469fb57d7d176b2022-12-22T03:00:53ZengTianjin Huanhu HospitalChinese Journal of Contemporary Neurology and Neurosurgery1672-67312022-11-01221199399910.3969/j.issn.1672⁃6731.2022.11.012Survival analysis of postoperative recurrence of meningioma: 176 cases reportHUANG Guan⁃you0 HAO Shu⁃yu1WANG Liang2 ZHANG Li⁃wei3ZHANG Jun⁃ting4 WU Zhen5Department of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityDepartment of Neurosurgery, Beijing Tiantan Hospital, Capital Medical UniversityObjective To investigate the influencing factors of postoperative meningioma recurrence. Methods A total of 176 patients with meningioma treated in Beijing Tiantan Hospital, Capital Medical University from May 2010 to January 2011 were included. The general information, imaging findings, extent of tumor resection and postoperative pathological results were analyzed. Kaplan⁃Meier survival curve comparison and Log⁃rank test were used to compare the related influencing factors of meningioma recurrence. Multifactor Cox's proportional hazards regression model was used for survival analysis. Results The median progression free survival (PFS) of patients with preoperative Karnofsky Performance Status (KPS)＜70 was lower than that with KPS≥70 [(8.04±1.98) years vs. (8.08±1.18) years; χ2=5.370, P=0.020]. The median PFS of patients with peritumoral edema grade 2-3 was lower than that with peritumoral edema grade 0-1 [(8.05±1.79) years vs. (8.06±1.09) years; χ2=9.805, P=0.002]. The median PFS of patients with dural mater invasion was lower than that without dural mater invasion [(7.97±1.70) years vs. (8.06±1.09) years; χ2=12.357, P=0.000]. The median PFS of patients with WHO grade 2-3 was lower than that with WHO grade 1 [(5.14±2.07) years vs. (8.12±0.87) years; χ2=113.774, P=0.000]. Multivariate Cox's proportional hazards regression model showed that WHO grade 2-3 could increase the risk of postoperative meningioma recurrence (RR=15.693, 95%CI: 5.905-41.707; P=0.000). Conclusions The preoperative KPS score, peritumoral edema, dura mater invasion and WHO grade may affect the recurrence of meningioma, and WHO grade 2-3 can increase the risk of meningioma recurrence.http://www.cjcnn.org/index.php/cjcnn/article/view/2594meningiomamicrosurgeryrecurrenceproportional hazards modelsprogression⁃ free survival |
| spellingShingle | HUANG Guan⁃you HAO Shu⁃yu WANG Liang ZHANG Li⁃wei ZHANG Jun⁃ting WU Zhen Survival analysis of postoperative recurrence of meningioma: 176 cases report Chinese Journal of Contemporary Neurology and Neurosurgery meningioma microsurgery recurrence proportional hazards models progression⁃ free survival |
| title | Survival analysis of postoperative recurrence of meningioma: 176 cases report |
| title_full | Survival analysis of postoperative recurrence of meningioma: 176 cases report |
| title_fullStr | Survival analysis of postoperative recurrence of meningioma: 176 cases report |
| title_full_unstemmed | Survival analysis of postoperative recurrence of meningioma: 176 cases report |
| title_short | Survival analysis of postoperative recurrence of meningioma: 176 cases report |
| title_sort | survival analysis of postoperative recurrence of meningioma 176 cases report |
| topic | meningioma microsurgery recurrence proportional hazards models progression⁃ free survival |
| url | http://www.cjcnn.org/index.php/cjcnn/article/view/2594 |
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