Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone
Previous data have shown both in the rat and in the human that a single mandibular extension lasting 10 min induces a significant important and prolonged reduction in blood pressure and heart rate, affecting also rat pial microcirculation by the release of endothelial factors. In the present work, w...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2017-08-01
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| Series: | Frontiers in Physiology |
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| Online Access: | http://journal.frontiersin.org/article/10.3389/fphys.2017.00625/full |
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| author | Dominga Lapi Maurizio Varanini Antonio Colantuoni Cristina Del Seppia Sergio Ghione Enza Fommei Rossana Scuri |
| author_facet | Dominga Lapi Maurizio Varanini Antonio Colantuoni Cristina Del Seppia Sergio Ghione Enza Fommei Rossana Scuri |
| author_sort | Dominga Lapi |
| collection | DOAJ |
| description | Previous data have shown both in the rat and in the human that a single mandibular extension lasting 10 min induces a significant important and prolonged reduction in blood pressure and heart rate, affecting also rat pial microcirculation by the release of endothelial factors. In the present work, we assessed whether repeated mandibular extension could further prolong these effects. We performed two mandibular extensions, the second mandibular extension being applied 10 min after the first one. The second mandibular extension produced a reduction in blood pressure and heart rate for at least 240 min. As in the case of a single mandibular extension, pial arterioles dilated persisting up to 140 min after the second extension. Spectral analysis on 30 min recordings under baseline conditions and after repetitive mandibular extensions showed that the pial arterioles dilation was associated with rhythmic diameter changes sustained by an increase in the frequency components related to endothelial, neurogenic, and myogenic activity while a single mandibular extension caused, conversely, an increase only in the endothelial activity. In conclusion, repetitive mandibular extension prolonged the effects of a single mandibular extension on blood pressure, heart rate and vasodilation and induced a modulation of different frequency components responsible of the pial arteriolar tone, in particular increasing the endothelial activity. |
| first_indexed | 2024-04-14T01:10:13Z |
| format | Article |
| id | doaj.art-55964a01284b4f92843e616ab5b811e3 |
| institution | Directory Open Access Journal |
| issn | 1664-042X |
| language | English |
| last_indexed | 2024-04-14T01:10:13Z |
| publishDate | 2017-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Physiology |
| spelling | doaj.art-55964a01284b4f92843e616ab5b811e32022-12-22T02:21:07ZengFrontiers Media S.A.Frontiers in Physiology1664-042X2017-08-01810.3389/fphys.2017.00625268248Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar ToneDominga Lapi0Maurizio Varanini1Antonio Colantuoni2Cristina Del Seppia3Sergio Ghione4Enza Fommei5Rossana Scuri6Department of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico IINaples, ItalyInstitute of Clinical Physiology, National Council of ResearchPisa, ItalyDepartment of Clinical Medicine and Surgery, School of Medicine, University of Naples Federico IINaples, ItalyInstitute of Clinical Physiology, National Council of ResearchPisa, ItalyMedical and Public Health Research, Fondazione Toscana Gabriele Monasterio (CNR)Pisa, ItalyMedical and Public Health Research, Fondazione Toscana Gabriele Monasterio (CNR)Pisa, ItalyDepartment of Translational Research on New Technologies in Medicine and Surgery, University of PisaPisa, ItalyPrevious data have shown both in the rat and in the human that a single mandibular extension lasting 10 min induces a significant important and prolonged reduction in blood pressure and heart rate, affecting also rat pial microcirculation by the release of endothelial factors. In the present work, we assessed whether repeated mandibular extension could further prolong these effects. We performed two mandibular extensions, the second mandibular extension being applied 10 min after the first one. The second mandibular extension produced a reduction in blood pressure and heart rate for at least 240 min. As in the case of a single mandibular extension, pial arterioles dilated persisting up to 140 min after the second extension. Spectral analysis on 30 min recordings under baseline conditions and after repetitive mandibular extensions showed that the pial arterioles dilation was associated with rhythmic diameter changes sustained by an increase in the frequency components related to endothelial, neurogenic, and myogenic activity while a single mandibular extension caused, conversely, an increase only in the endothelial activity. In conclusion, repetitive mandibular extension prolonged the effects of a single mandibular extension on blood pressure, heart rate and vasodilation and induced a modulation of different frequency components responsible of the pial arteriolar tone, in particular increasing the endothelial activity.http://journal.frontiersin.org/article/10.3389/fphys.2017.00625/fullarteriolar diameter changesblood pressureendothelial activityheart ratemandibular extensionpial microcirculation |
| spellingShingle | Dominga Lapi Maurizio Varanini Antonio Colantuoni Cristina Del Seppia Sergio Ghione Enza Fommei Rossana Scuri Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone Frontiers in Physiology arteriolar diameter changes blood pressure endothelial activity heart rate mandibular extension pial microcirculation |
| title | Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone |
| title_full | Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone |
| title_fullStr | Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone |
| title_full_unstemmed | Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone |
| title_short | Repeated Mandibular Extension in Rat: A Procedure to Modulate the Cerebral Arteriolar Tone |
| title_sort | repeated mandibular extension in rat a procedure to modulate the cerebral arteriolar tone |
| topic | arteriolar diameter changes blood pressure endothelial activity heart rate mandibular extension pial microcirculation |
| url | http://journal.frontiersin.org/article/10.3389/fphys.2017.00625/full |
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