The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients
Patients on maintenance hemodialysis are at high risk for cardiovascular morbidity and mortality. Fluid overload is generally regarded as the main cause of cardiovascular death among them. Cardiothoracic ratio (CTR) by chest plain film is routinely performed to evaluate their volumetric states and c...
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MDPI AG
2021-08-01
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| author | An-Ting Lee Yen-Pei Lu Chun-Hao Chen Chia-Hao Chang Yuan-Hsiung Tsai Chun-Wu Tung Jen-Tsung Yang |
| author_facet | An-Ting Lee Yen-Pei Lu Chun-Hao Chen Chia-Hao Chang Yuan-Hsiung Tsai Chun-Wu Tung Jen-Tsung Yang |
| author_sort | An-Ting Lee |
| collection | DOAJ |
| description | Patients on maintenance hemodialysis are at high risk for cardiovascular morbidity and mortality. Fluid overload is generally regarded as the main cause of cardiovascular death among them. Cardiothoracic ratio (CTR) by chest plain film is routinely performed to evaluate their volumetric states and cardiac conditions. We recently reported that salivary conductivity is a reliable marker for assessing fluid status in healthy adults. This cross-sectional study aims to explore the association between salivary conductivity and CTR. Cardiomegaly is defined as a CTR greater than 0.5. A total of 129 hemodialysis patients were enrolled, 42 of whom (32.6%) had cardiomegaly. Patients with cardiomegaly had significantly lower serum osmolality, lower serum sodium, and lower salivary conductivity, but a higher percentage of underlying atrial fibrillation. In the multiple linear regression analysis, CTR was negatively associated with salivary conductivity or to the serum sodium level and positively correlated with older age. We further divided patients into low, medium, and high salivary conductivity groups according to the tertials of conductivity levels. There was a significant trend for the increment of cardiomegaly from high to low salivary conductivity groups (<i>p</i> for trend: 0.021). The receiver operating characteristic curves for the diagnostic ability of salivary conductivity on cardiomegaly reported the area under the curve equal to 0.626 (95% CI: 0.521–0.730, <i>p</i> = 0.02). Moreover, older age and higher serum osmolality were independent determinants for salivary conductivity by multiple linear regression analysis. This work has presented that salivary conductivity is a novel approach to uncover fluid overload and cardiomegaly among chronic hemodialysis patients. |
| first_indexed | 2024-03-10T09:02:18Z |
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| language | English |
| last_indexed | 2024-03-10T09:02:18Z |
| publishDate | 2021-08-01 |
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| series | Applied Sciences |
| spelling | doaj.art-55975135c6d74b8eb2908342f83b7a722023-11-22T06:41:08ZengMDPI AGApplied Sciences2076-34172021-08-011116740510.3390/app11167405The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis PatientsAn-Ting Lee0Yen-Pei Lu1Chun-Hao Chen2Chia-Hao Chang3Yuan-Hsiung Tsai4Chun-Wu Tung5Jen-Tsung Yang6Department of Anesthesiology, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanTaiwan Instrument Research Institute, National Applied Research Laboratories, Hsinchu 30261, TaiwanDepartment of Orthopedic Surgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Nursing, Chiayi Campus, Chang Gung University of Science and Technology, Chiayi 61363, TaiwanDepartment of Diagnostic Radiology, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Nephrology, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanDepartment of Neurosurgery, Chang Gung Memorial Hospital, Chiayi 61363, TaiwanPatients on maintenance hemodialysis are at high risk for cardiovascular morbidity and mortality. Fluid overload is generally regarded as the main cause of cardiovascular death among them. Cardiothoracic ratio (CTR) by chest plain film is routinely performed to evaluate their volumetric states and cardiac conditions. We recently reported that salivary conductivity is a reliable marker for assessing fluid status in healthy adults. This cross-sectional study aims to explore the association between salivary conductivity and CTR. Cardiomegaly is defined as a CTR greater than 0.5. A total of 129 hemodialysis patients were enrolled, 42 of whom (32.6%) had cardiomegaly. Patients with cardiomegaly had significantly lower serum osmolality, lower serum sodium, and lower salivary conductivity, but a higher percentage of underlying atrial fibrillation. In the multiple linear regression analysis, CTR was negatively associated with salivary conductivity or to the serum sodium level and positively correlated with older age. We further divided patients into low, medium, and high salivary conductivity groups according to the tertials of conductivity levels. There was a significant trend for the increment of cardiomegaly from high to low salivary conductivity groups (<i>p</i> for trend: 0.021). The receiver operating characteristic curves for the diagnostic ability of salivary conductivity on cardiomegaly reported the area under the curve equal to 0.626 (95% CI: 0.521–0.730, <i>p</i> = 0.02). Moreover, older age and higher serum osmolality were independent determinants for salivary conductivity by multiple linear regression analysis. This work has presented that salivary conductivity is a novel approach to uncover fluid overload and cardiomegaly among chronic hemodialysis patients.https://www.mdpi.com/2076-3417/11/16/7405salivary conductivitycardiomegalyportable biodeviceend-stage kidney diseasehemodialysis |
| spellingShingle | An-Ting Lee Yen-Pei Lu Chun-Hao Chen Chia-Hao Chang Yuan-Hsiung Tsai Chun-Wu Tung Jen-Tsung Yang The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients Applied Sciences salivary conductivity cardiomegaly portable biodevice end-stage kidney disease hemodialysis |
| title | The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients |
| title_full | The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients |
| title_fullStr | The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients |
| title_full_unstemmed | The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients |
| title_short | The Association of Salivary Conductivity with Cardiomegaly in Hemodialysis Patients |
| title_sort | association of salivary conductivity with cardiomegaly in hemodialysis patients |
| topic | salivary conductivity cardiomegaly portable biodevice end-stage kidney disease hemodialysis |
| url | https://www.mdpi.com/2076-3417/11/16/7405 |
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