The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus
Background. Сardiotrophin-1 is thought to be one of the key regulator of cardiac hypertrophy and hyperplasia, and has influence on apoptosis intensity and sensitivity to ischemia. Objective. The aim of the investigation was to study the role of cardiotrophin-1 in pathological myocardial remodeling i...
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| Format: | Article |
| Language: | Russian |
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Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy
2013-01-01
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| Series: | Морфологія |
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| Online Access: | http://www.morphology.dp.ua/_pub/MORPHO-2013-07-03/13kmyesd.pdf |
| _version_ | 1818177925104533504 |
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| author | Kolesnyk M.Yu. |
| author_facet | Kolesnyk M.Yu. |
| author_sort | Kolesnyk M.Yu. |
| collection | DOAJ |
| description | Background. Сardiotrophin-1 is thought to be one of the key regulator of cardiac hypertrophy and hyperplasia, and has influence on apoptosis intensity and sensitivity to ischemia. Objective. The aim of the investigation was to study the role of cardiotrophin-1 in pathological myocardial remodeling in arterial hypertension with diabetes. Methods. Spontaneous hypertensive rats with experimental diabetes were used in the study. The expression of cardiotrophin-1 was analyzed by immunohystochemical method. Apoptitic cells were confirmed by annexin V detection. Results. It was found that cardiac content of cardiotrophin-1 was 2.6-fold higher in myocardium of hypertensive rats with diabetes in comparison with rats without diabetes. The concentration of annexin V was slightly increased in animals with experimental diabetes. Conclusion. The high content of cardiotrophin-1 in hypertension with diabetes is thought to be the factor which decreases the intensity of caridomyocytes’ apoptosis. |
| first_indexed | 2024-12-11T20:39:49Z |
| format | Article |
| id | doaj.art-5598f7bcc3144846a49d2a295ccdf679 |
| institution | Directory Open Access Journal |
| issn | 1997-9665 |
| language | Russian |
| last_indexed | 2024-12-11T20:39:49Z |
| publishDate | 2013-01-01 |
| publisher | Ministry of Health of Ukraine. Dnipropetrovsk Medical Academy |
| record_format | Article |
| series | Морфологія |
| spelling | doaj.art-5598f7bcc3144846a49d2a295ccdf6792022-12-22T00:51:32ZrusMinistry of Health of Ukraine. Dnipropetrovsk Medical AcademyМорфологія1997-96652013-01-01736064The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitusKolesnyk M.Yu.Background. Сardiotrophin-1 is thought to be one of the key regulator of cardiac hypertrophy and hyperplasia, and has influence on apoptosis intensity and sensitivity to ischemia. Objective. The aim of the investigation was to study the role of cardiotrophin-1 in pathological myocardial remodeling in arterial hypertension with diabetes. Methods. Spontaneous hypertensive rats with experimental diabetes were used in the study. The expression of cardiotrophin-1 was analyzed by immunohystochemical method. Apoptitic cells were confirmed by annexin V detection. Results. It was found that cardiac content of cardiotrophin-1 was 2.6-fold higher in myocardium of hypertensive rats with diabetes in comparison with rats without diabetes. The concentration of annexin V was slightly increased in animals with experimental diabetes. Conclusion. The high content of cardiotrophin-1 in hypertension with diabetes is thought to be the factor which decreases the intensity of caridomyocytes’ apoptosis.http://www.morphology.dp.ua/_pub/MORPHO-2013-07-03/13kmyesd.pdfcardiotrophin-1annexin Vmyocardiumexperimental diabetes mellitusspontaneous hypertensive rats |
| spellingShingle | Kolesnyk M.Yu. The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus Морфологія cardiotrophin-1 annexin V myocardium experimental diabetes mellitus spontaneous hypertensive rats |
| title | The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus |
| title_full | The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus |
| title_fullStr | The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus |
| title_full_unstemmed | The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus |
| title_short | The role of cardiotrophin-1 and annexin V in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus |
| title_sort | role of cardiotrophin 1 and annexin v in myocardial remodelling of spontaneous hypertensive rats with experimental diabetes mellitus |
| topic | cardiotrophin-1 annexin V myocardium experimental diabetes mellitus spontaneous hypertensive rats |
| url | http://www.morphology.dp.ua/_pub/MORPHO-2013-07-03/13kmyesd.pdf |
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