Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology

Generation of a SARS-CoV-2 Reverse Genetics System and Novel Human Lung Cell Lines That Exhibit High Virus-Induced Cytopathology

The global COVID-19 pandemic continues with continued cases worldwide and the emergence of new SARS-CoV-2 variants. In our study, we have developed novel tools with applications for screening antivirals, identifying virus–host dependencies, and characterizing viral variants. Using reverse genetics,...

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Bibliographic Details
Main Authors: Juveriya Qamar Khan, Megha Rohamare, Karthic Rajamanickam, Kalpana K. Bhanumathy, Jocelyne Lew, Anil Kumar, Darryl Falzarano, Franco J. Vizeacoumar, Joyce A. Wilson
Format: Article
Language:English
Published: MDPI AG 2023-05-01
Series:Viruses
Subjects:
SARS-CoV-2
human lung cell lines
COVID-19
reverse genetics
reporter viruses
Online Access:https://www.mdpi.com/1999-4915/15/6/1281

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