Study of optical coherence tomography angiography for neovascular age-related macular degeneration
AIM: To analyze the characteristics of choroidal neovascularization(CNV)in neovascular age-related macular degeneration(nARMD)patients and the outcome of intravitreal anti-vascular endothelial growth factor(VEGF)treatment by using optical coherence tomography angiography(OCTA). <p>METHODS: A p...
| Main Authors: | , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Press of International Journal of Ophthalmology (IJO PRESS)
2018-12-01
|
| Series: | Guoji Yanke Zazhi |
| Subjects: | |
| Online Access: | http://ies.ijo.cn/cn_publish/2018/12/201812031.pdf |
| _version_ | 1818454617421250560 |
|---|---|
| author | Xiao-Xue Min Si-Rui Zhou Jia Mu Yi-Lin Liu Ming Zhang |
| author_facet | Xiao-Xue Min Si-Rui Zhou Jia Mu Yi-Lin Liu Ming Zhang |
| author_sort | Xiao-Xue Min |
| collection | DOAJ |
| description | AIM: To analyze the characteristics of choroidal neovascularization(CNV)in neovascular age-related macular degeneration(nARMD)patients and the outcome of intravitreal anti-vascular endothelial growth factor(VEGF)treatment by using optical coherence tomography angiography(OCTA). <p>METHODS: A prospective cohort study was carried out, which included 37 eyes of 29 patients with nARMD in West China Hospital during May to December 2017. OCTA scans was conducted to all patients before treatment, 1d, 1wk, 1mo and 3-6mo after treatment. The analysis was performed to evaluate the morphological characteristics, lesion area, parafoveal superficial vessel density and perfusion area of CNV before and after treatment. <p>RESULTS: Among all the subjects, immature structure, small branches, and capillaries responded well to anti-VEGF treatment. Compared with the mean lesion area in nARMD patients before treatment(1.27±1.88mm<sup>2</sup>), there was significant reduction(1.13±1.79 mm<sup>2</sup>)1d after treatment, which meant CNV lesion decreased 1d after treatment, and stabilized 1mo later(<i>P</i>=0.001). Obvious decrease was observed both in parafoveal superficial vessel density(<i>P</i>=0.003)and perfusion area(<i>P</i>=0.015)3mo after treatment in nARMD patients. <p>CONCLUSION: OCTA, a non-invasive diagnostic examination, clearly identified tiny structures of CNV, quantified the lesion area and displayed specific vasculature in nARMD patients. Furthermore, retinal microcirculation can be detected using OCTA, which provides an effective approach of monitoring the progression and treatment effect of nARMD. |
| first_indexed | 2024-12-14T21:57:44Z |
| format | Article |
| id | doaj.art-559c97c361774c5b9eefd201f581bc01 |
| institution | Directory Open Access Journal |
| issn | 1672-5123 1672-5123 |
| language | English |
| last_indexed | 2024-12-14T21:57:44Z |
| publishDate | 2018-12-01 |
| publisher | Press of International Journal of Ophthalmology (IJO PRESS) |
| record_format | Article |
| series | Guoji Yanke Zazhi |
| spelling | doaj.art-559c97c361774c5b9eefd201f581bc012022-12-21T22:46:04ZengPress of International Journal of Ophthalmology (IJO PRESS)Guoji Yanke Zazhi1672-51231672-51232018-12-0118122248225210.3980/j.issn.1672-5123.2018.12.31Study of optical coherence tomography angiography for neovascular age-related macular degenerationXiao-Xue Min0Si-Rui Zhou1Jia Mu2Yi-Lin Liu3Ming Zhang4Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, ChinaDepartment of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, ChinaAIM: To analyze the characteristics of choroidal neovascularization(CNV)in neovascular age-related macular degeneration(nARMD)patients and the outcome of intravitreal anti-vascular endothelial growth factor(VEGF)treatment by using optical coherence tomography angiography(OCTA). <p>METHODS: A prospective cohort study was carried out, which included 37 eyes of 29 patients with nARMD in West China Hospital during May to December 2017. OCTA scans was conducted to all patients before treatment, 1d, 1wk, 1mo and 3-6mo after treatment. The analysis was performed to evaluate the morphological characteristics, lesion area, parafoveal superficial vessel density and perfusion area of CNV before and after treatment. <p>RESULTS: Among all the subjects, immature structure, small branches, and capillaries responded well to anti-VEGF treatment. Compared with the mean lesion area in nARMD patients before treatment(1.27±1.88mm<sup>2</sup>), there was significant reduction(1.13±1.79 mm<sup>2</sup>)1d after treatment, which meant CNV lesion decreased 1d after treatment, and stabilized 1mo later(<i>P</i>=0.001). Obvious decrease was observed both in parafoveal superficial vessel density(<i>P</i>=0.003)and perfusion area(<i>P</i>=0.015)3mo after treatment in nARMD patients. <p>CONCLUSION: OCTA, a non-invasive diagnostic examination, clearly identified tiny structures of CNV, quantified the lesion area and displayed specific vasculature in nARMD patients. Furthermore, retinal microcirculation can be detected using OCTA, which provides an effective approach of monitoring the progression and treatment effect of nARMD.http://ies.ijo.cn/cn_publish/2018/12/201812031.pdfoptical coherence tomography angiographyneovascular age-related macular degenerationvascular endothelial growth factorchoroidal neovascularization |
| spellingShingle | Xiao-Xue Min Si-Rui Zhou Jia Mu Yi-Lin Liu Ming Zhang Study of optical coherence tomography angiography for neovascular age-related macular degeneration Guoji Yanke Zazhi optical coherence tomography angiography neovascular age-related macular degeneration vascular endothelial growth factor choroidal neovascularization |
| title | Study of optical coherence tomography angiography for neovascular age-related macular degeneration |
| title_full | Study of optical coherence tomography angiography for neovascular age-related macular degeneration |
| title_fullStr | Study of optical coherence tomography angiography for neovascular age-related macular degeneration |
| title_full_unstemmed | Study of optical coherence tomography angiography for neovascular age-related macular degeneration |
| title_short | Study of optical coherence tomography angiography for neovascular age-related macular degeneration |
| title_sort | study of optical coherence tomography angiography for neovascular age related macular degeneration |
| topic | optical coherence tomography angiography neovascular age-related macular degeneration vascular endothelial growth factor choroidal neovascularization |
| url | http://ies.ijo.cn/cn_publish/2018/12/201812031.pdf |
| work_keys_str_mv | AT xiaoxuemin studyofopticalcoherencetomographyangiographyforneovascularagerelatedmaculardegeneration AT siruizhou studyofopticalcoherencetomographyangiographyforneovascularagerelatedmaculardegeneration AT jiamu studyofopticalcoherencetomographyangiographyforneovascularagerelatedmaculardegeneration AT yilinliu studyofopticalcoherencetomographyangiographyforneovascularagerelatedmaculardegeneration AT mingzhang studyofopticalcoherencetomographyangiographyforneovascularagerelatedmaculardegeneration |