Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia
Cell-free mitochondrial DNA (cf-mtDNA) is a damage-associated molecular pattern that boosts the release of cytokines and induces the immune response of the body; therefore, it is closely related to mental diseases. This study aims to evaluate a potential link between cf-mtDNA and clinical progressio...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-07-01
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| Series: | Frontiers in Psychiatry |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.652314/full |
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| author | Houxian Ouyang Houxian Ouyang Minfang Huang Minfang Huang Yongming Xu Qin Yao Qin Yao Xiangping Wu Dongsheng Zhou Dongsheng Zhou |
| author_facet | Houxian Ouyang Houxian Ouyang Minfang Huang Minfang Huang Yongming Xu Qin Yao Qin Yao Xiangping Wu Dongsheng Zhou Dongsheng Zhou |
| author_sort | Houxian Ouyang |
| collection | DOAJ |
| description | Cell-free mitochondrial DNA (cf-mtDNA) is a damage-associated molecular pattern that boosts the release of cytokines and induces the immune response of the body; therefore, it is closely related to mental diseases. This study aims to evaluate a potential link between cf-mtDNA and clinical progression in first-episode patients with schizophrenia. In this study, plasma cf-mtDNA levels in 34 first-episode patients with schizophrenia before and after 8 weeks of antipsychotic treatment were examined. In addition, the clinical progression of first-episode schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). The copy number changes in the plasma cf-mtDNA (Δcf-mtDNA) were significantly correlated with changes in the PANSS scale scores (ΔPANSS) in first-episode patients with schizophrenia (ΔPANSS total score, P = 0.002; ΔPANSS positive score, P = 0.01). Plasma cf-mtDNA may represent a relevant tool in the future to assist in the assessment of clinical progression in first-episode patients with schizophrenia. |
| first_indexed | 2024-12-19T05:49:07Z |
| format | Article |
| id | doaj.art-559e45b05c434c54bcf43ecc5691ca46 |
| institution | Directory Open Access Journal |
| issn | 1664-0640 |
| language | English |
| last_indexed | 2024-12-19T05:49:07Z |
| publishDate | 2021-07-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Psychiatry |
| spelling | doaj.art-559e45b05c434c54bcf43ecc5691ca462022-12-21T20:33:42ZengFrontiers Media S.A.Frontiers in Psychiatry1664-06402021-07-011210.3389/fpsyt.2021.652314652314Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With SchizophreniaHouxian Ouyang0Houxian Ouyang1Minfang Huang2Minfang Huang3Yongming Xu4Qin Yao5Qin Yao6Xiangping Wu7Dongsheng Zhou8Dongsheng Zhou9Department of Psychiatry, Ningbo Kangning Hospital, Ningbo, ChinaDepartment of Laboratory Diagnostics, Ningbo Kangning Hospital, Ningbo, ChinaDepartment of Psychiatry, Ningbo Kangning Hospital, Ningbo, ChinaDepartment of Pharmacology, Ningbo Kangning Hospital, Ningbo, ChinaDepartment of Psychiatry, Ningbo Kangning Hospital, Ningbo, ChinaDepartment of Psychiatry, Ningbo Kangning Hospital, Ningbo, ChinaNingbo Key Laboratory of Sleep Medicine, Ningbo, ChinaDepartment of Psychiatry, Ningbo Kangning Hospital, Ningbo, ChinaDepartment of Psychiatry, Ningbo Kangning Hospital, Ningbo, ChinaNingbo Key Laboratory of Sleep Medicine, Ningbo, ChinaCell-free mitochondrial DNA (cf-mtDNA) is a damage-associated molecular pattern that boosts the release of cytokines and induces the immune response of the body; therefore, it is closely related to mental diseases. This study aims to evaluate a potential link between cf-mtDNA and clinical progression in first-episode patients with schizophrenia. In this study, plasma cf-mtDNA levels in 34 first-episode patients with schizophrenia before and after 8 weeks of antipsychotic treatment were examined. In addition, the clinical progression of first-episode schizophrenia was assessed using the Positive and Negative Syndrome Scale (PANSS). The copy number changes in the plasma cf-mtDNA (Δcf-mtDNA) were significantly correlated with changes in the PANSS scale scores (ΔPANSS) in first-episode patients with schizophrenia (ΔPANSS total score, P = 0.002; ΔPANSS positive score, P = 0.01). Plasma cf-mtDNA may represent a relevant tool in the future to assist in the assessment of clinical progression in first-episode patients with schizophrenia.https://www.frontiersin.org/articles/10.3389/fpsyt.2021.652314/fullfirst-episode schizophreniacell-free mitochondrial DNApositive and negative syndrome scaleclinical progressionantipsychotics |
| spellingShingle | Houxian Ouyang Houxian Ouyang Minfang Huang Minfang Huang Yongming Xu Qin Yao Qin Yao Xiangping Wu Dongsheng Zhou Dongsheng Zhou Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia Frontiers in Psychiatry first-episode schizophrenia cell-free mitochondrial DNA positive and negative syndrome scale clinical progression antipsychotics |
| title | Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia |
| title_full | Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia |
| title_fullStr | Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia |
| title_full_unstemmed | Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia |
| title_short | Reduced Cell-Free Mitochondrial DNA Levels Were Induced by Antipsychotics Treatment in First-Episode Patients With Schizophrenia |
| title_sort | reduced cell free mitochondrial dna levels were induced by antipsychotics treatment in first episode patients with schizophrenia |
| topic | first-episode schizophrenia cell-free mitochondrial DNA positive and negative syndrome scale clinical progression antipsychotics |
| url | https://www.frontiersin.org/articles/10.3389/fpsyt.2021.652314/full |
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