Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report
It is uncommon for a patient with Alcoholic Liver Disease (ALD) to arrive with solitary hyperbilirubinaemia that is not accompanied by substantial hepatic abnormalities. Patients with ALD are more likely to develop bacterial and Invasive Fungal Infections (IFI) early in the course of their disease a...
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JCDR Research and Publications Private Limited
2023-05-01
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| Series: | Journal of Clinical and Diagnostic Research |
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| Online Access: | https://www.jcdr.net/articles/PDF/17925/60417_CE[Ra1]_F(IS)_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf |
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| author | Rashmi Mishra Sandeep Garg Raghu V Gowda Praveen Bharti Priya Sharma |
| author_facet | Rashmi Mishra Sandeep Garg Raghu V Gowda Praveen Bharti Priya Sharma |
| author_sort | Rashmi Mishra |
| collection | DOAJ |
| description | It is uncommon for a patient with Alcoholic Liver Disease (ALD) to arrive with solitary hyperbilirubinaemia that is not accompanied by substantial hepatic abnormalities. Patients with ALD are more likely to develop bacterial and Invasive Fungal Infections (IFI) early in the course of their disease and both are linked with more severe systemic inflammation, a poorer clinical prognosis, and a higher mortality. Because of escalating antibiotic usage, lengthy hospital stays, and intensive medical procedures, hospitalised cirrhotic patients are increasingly at risk of acquiring IFI. In patients with alcoholic liver failure, persistent IFI are a primary cause of death and treatment resistance. This was a case of a 34-year-old male with an unusual combination of worsening sepsis and worsening jaundice without any other significant abnormalities in liver function. He was given adequate antibiotics to treat the isolated organism Escherichia coli (E. coli), but his pneumonia persisted. After positive tests for an IFI, he was given antifungal medications as well. He failed to improve and finally gave into his illness. |
| first_indexed | 2024-03-13T09:58:34Z |
| format | Article |
| id | doaj.art-559fa846cc764feb8c4a56bc36a4c840 |
| institution | Directory Open Access Journal |
| issn | 2249-782X 0973-709X |
| language | English |
| last_indexed | 2024-03-13T09:58:34Z |
| publishDate | 2023-05-01 |
| publisher | JCDR Research and Publications Private Limited |
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| series | Journal of Clinical and Diagnostic Research |
| spelling | doaj.art-559fa846cc764feb8c4a56bc36a4c8402023-05-23T11:45:25ZengJCDR Research and Publications Private LimitedJournal of Clinical and Diagnostic Research2249-782X0973-709X2023-05-01175OD01OD0410.7860/JCDR/2023/60417.17925Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case ReportRashmi Mishra0Sandeep Garg1Raghu V Gowda2Praveen Bharti3Priya Sharma4Senior Resident, Department of Medicine, Maulana Azad Medical College, New Delhi, India.Director Professor, Department of Medicine, Maulana Azad Medical College, New Delhi, India.Senior Resident, Department of Medicine, Maulana Azad Medical College, New Delhi, India.Associate Professor, Department of Medicine, Maulana Azad Medical College, New Delhi, India.Postgraduate Student, Department of Medicine, Maulana Azad Medical College, New Delhi, India.It is uncommon for a patient with Alcoholic Liver Disease (ALD) to arrive with solitary hyperbilirubinaemia that is not accompanied by substantial hepatic abnormalities. Patients with ALD are more likely to develop bacterial and Invasive Fungal Infections (IFI) early in the course of their disease and both are linked with more severe systemic inflammation, a poorer clinical prognosis, and a higher mortality. Because of escalating antibiotic usage, lengthy hospital stays, and intensive medical procedures, hospitalised cirrhotic patients are increasingly at risk of acquiring IFI. In patients with alcoholic liver failure, persistent IFI are a primary cause of death and treatment resistance. This was a case of a 34-year-old male with an unusual combination of worsening sepsis and worsening jaundice without any other significant abnormalities in liver function. He was given adequate antibiotics to treat the isolated organism Escherichia coli (E. coli), but his pneumonia persisted. After positive tests for an IFI, he was given antifungal medications as well. He failed to improve and finally gave into his illness.https://www.jcdr.net/articles/PDF/17925/60417_CE[Ra1]_F(IS)_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdfcirrhosisjaundicenon resolving pneumoniatuberculosis |
| spellingShingle | Rashmi Mishra Sandeep Garg Raghu V Gowda Praveen Bharti Priya Sharma Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report Journal of Clinical and Diagnostic Research cirrhosis jaundice non resolving pneumonia tuberculosis |
| title | Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report |
| title_full | Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report |
| title_fullStr | Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report |
| title_full_unstemmed | Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report |
| title_short | Atypical Presentation of Alcoholic Liver Disease as Isolated Direct Hyperbilirubinaemia with Non Resolving Pneumonia Secondary to Multidrug Resistant Escherichia coli and Aspergillus Co-infection: A Case Report |
| title_sort | atypical presentation of alcoholic liver disease as isolated direct hyperbilirubinaemia with non resolving pneumonia secondary to multidrug resistant escherichia coli and aspergillus co infection a case report |
| topic | cirrhosis jaundice non resolving pneumonia tuberculosis |
| url | https://www.jcdr.net/articles/PDF/17925/60417_CE[Ra1]_F(IS)_PF1(AG_SS)_PFA(AG_KM)_PN(KM).pdf |
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