Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient
Hypokalemia with rhabdomyolysis caused by diarrhoea is uncommon in human immunodeficiency virus (HIV) infected patients. We report the case of a patient with HIV1 infection who presented with chronic diarrhoea that led to hypokalemia induced rhabdomyolysis and acute kidney injury (AKI). A 32-year-o...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2015-04-01
|
| Series: | Journal of Clinical and Scientific Research |
| Subjects: | |
| Online Access: | http://svimstpt.ap.nic.in/jcsr/apr-jun15_files/2cr215.pdf |
| _version_ | 1828143548327788544 |
|---|---|
| author | Swaroopa K Murali Krishna M Raju YSN Subbalaxmi MVS Chandra N Khan SA |
| author_facet | Swaroopa K Murali Krishna M Raju YSN Subbalaxmi MVS Chandra N Khan SA |
| author_sort | Swaroopa K |
| collection | DOAJ |
| description | Hypokalemia with rhabdomyolysis caused by diarrhoea is uncommon in human immunodeficiency virus (HIV) infected patients. We report the case of a patient with HIV1 infection who presented with chronic diarrhoea that led to hypokalemia induced rhabdomyolysis and acute kidney injury (AKI). A 32-year-old
man, known to be HIV-1 seropositive who was on treatment with tenofovir, lamivudine, lopinavirand ritonavir, presented to the emergency department with 6 months history of diarrhoea and sudden onset of weakness of all 4 limbs of two days duration. On examination limb power was grade 3/5 with hypotonia and
diminished reflexes. Laboratory investigations showed severe hypokalemia, low urinary potassium, normal anion-gap metabolic acidosis, markedly increased creatine kinase and mildly increased serum creatinine. He was diagnosed as having diarrhoea induced hypokalemic myopathy leading to rhabdomyolysis and AKI. With potassium supplements, antiprotozoal treatment adequate hydration he improved significantly and is on regular follow-up. Patients presenting with hypokalemia should be closely monitored for rhabdomyolysis, because outcome is good with early treatment. |
| first_indexed | 2024-04-11T19:58:58Z |
| format | Article |
| id | doaj.art-559fdf176e834d7e91d1a7e0342b834a |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-04-11T19:58:58Z |
| publishDate | 2015-04-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-559fdf176e834d7e91d1a7e0342b834a2022-12-22T04:05:45ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572015-04-0142164168http://dx.doi.org/10.15380/2277-5706.JCSR.14.006Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patientSwaroopa K0Murali Krishna M1Raju YSN2Subbalaxmi MVS3Chandra N4Khan SA5Nizam’s Institute of Medical Sciences, HyderabadNizam’s Institute of Medical Sciences, HyderabadNizam’s Institute of Medical Sciences, HyderabadNizam’s Institute of Medical Sciences, HyderabadNizam’s Institute of Medical Sciences, HyderabadNizam’s Institute of Medical Sciences, HyderabadHypokalemia with rhabdomyolysis caused by diarrhoea is uncommon in human immunodeficiency virus (HIV) infected patients. We report the case of a patient with HIV1 infection who presented with chronic diarrhoea that led to hypokalemia induced rhabdomyolysis and acute kidney injury (AKI). A 32-year-old man, known to be HIV-1 seropositive who was on treatment with tenofovir, lamivudine, lopinavirand ritonavir, presented to the emergency department with 6 months history of diarrhoea and sudden onset of weakness of all 4 limbs of two days duration. On examination limb power was grade 3/5 with hypotonia and diminished reflexes. Laboratory investigations showed severe hypokalemia, low urinary potassium, normal anion-gap metabolic acidosis, markedly increased creatine kinase and mildly increased serum creatinine. He was diagnosed as having diarrhoea induced hypokalemic myopathy leading to rhabdomyolysis and AKI. With potassium supplements, antiprotozoal treatment adequate hydration he improved significantly and is on regular follow-up. Patients presenting with hypokalemia should be closely monitored for rhabdomyolysis, because outcome is good with early treatment.http://svimstpt.ap.nic.in/jcsr/apr-jun15_files/2cr215.pdfHIVDiarrhoeaHypokalemiaRhabdomyolysis |
| spellingShingle | Swaroopa K Murali Krishna M Raju YSN Subbalaxmi MVS Chandra N Khan SA Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient Journal of Clinical and Scientific Research HIV Diarrhoea Hypokalemia Rhabdomyolysis |
| title | Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient |
| title_full | Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient |
| title_fullStr | Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient |
| title_full_unstemmed | Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient |
| title_short | Rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus - seropositive patient |
| title_sort | rhabdomyolysis secondary to diarrhoea induced hypokalemia in a human immunodeficiency virus seropositive patient |
| topic | HIV Diarrhoea Hypokalemia Rhabdomyolysis |
| url | http://svimstpt.ap.nic.in/jcsr/apr-jun15_files/2cr215.pdf |
| work_keys_str_mv | AT swaroopak rhabdomyolysissecondarytodiarrhoeainducedhypokalemiainahumanimmunodeficiencyvirusseropositivepatient AT muralikrishnam rhabdomyolysissecondarytodiarrhoeainducedhypokalemiainahumanimmunodeficiencyvirusseropositivepatient AT rajuysn rhabdomyolysissecondarytodiarrhoeainducedhypokalemiainahumanimmunodeficiencyvirusseropositivepatient AT subbalaxmimvs rhabdomyolysissecondarytodiarrhoeainducedhypokalemiainahumanimmunodeficiencyvirusseropositivepatient AT chandran rhabdomyolysissecondarytodiarrhoeainducedhypokalemiainahumanimmunodeficiencyvirusseropositivepatient AT khansa rhabdomyolysissecondarytodiarrhoeainducedhypokalemiainahumanimmunodeficiencyvirusseropositivepatient |