CpxR promotes the carbapenem antibiotic resistance of Klebsiella pneumoniae by directly regulating the expression and the dissemination of blaKPC on the IncFII conjugative plasmid

CpxR promotes the carbapenem antibiotic resistance of Klebsiella pneumoniae by directly regulating the expression and the dissemination of blaKPC on the IncFII conjugative plasmid

ABSTRACTKlebsiella pneumoniae is an important human pathogen known for its resistance to carbapenem antibiotics, especially the increasing carbapenem-resistant hypervirulent variants. The carbapenem resistance is mainly caused by the carbapenemase gene blaKPC which was commonly found on the IncFII t...

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Bibliographic Details
Main Authors: Zhiyuan Liu, Jiahao Guan, Zhaoyan Chen, Cui Tai, Zixin Deng, Yanjie Chao, Hong-Yu Ou
Format: Article
Language:English
Published: Taylor & Francis Group 2023-12-01
Series:Emerging Microbes and Infections
Subjects:
Two-component system
CpxR
carbapenem resistance gene
plasmid conjugation
Klebsiella pneumoniae
Online Access:https://www.tandfonline.com/doi/10.1080/22221751.2023.2256427

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