Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting
Abstract Background Tuberculosis (TB) is among the world’s top public health challenges and the leading killer of people with HIV, yet is a treatable disease. This study aimed to assess, in a real-world setting, the implementation of antiretroviral therapy (ART) and Cotrimoxazole preventive therapy...
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| Format: | Article |
| Language: | English |
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BMC
2019-09-01
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| Series: | BMC Infectious Diseases |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s12879-019-4401-9 |
| _version_ | 1818971697018044416 |
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| author | Ley Muyaya Muyaya Esperance Manwana Musanda Jacques Lukenze Tamuzi |
| author_facet | Ley Muyaya Muyaya Esperance Manwana Musanda Jacques Lukenze Tamuzi |
| author_sort | Ley Muyaya Muyaya |
| collection | DOAJ |
| description | Abstract Background Tuberculosis (TB) is among the world’s top public health challenges and the leading killer of people with HIV, yet is a treatable disease. This study aimed to assess, in a real-world setting, the implementation of antiretroviral therapy (ART) and Cotrimoxazole preventive therapy (CPT) policy, specific interventions proven to benefit patients in HIV-associated TB care. Methods This retrospective cohort study was conducted in Botswana in the Serowe/Palapye district, a largely urban district with a high burden of HIV-associated TB with a high case fatality, at Segkoma and Palapye hospitals and their feeder clinics. Between 1 January 2013 and 31 December 2013, confirmed HIV-positive patients aged ≥15 years with a confirmed TB diagnosis and medical record available were included in the analysis. The Kaplan-Meier method was used to compare time to death for the group of patients on ART and the group of patients not on ART during TB treatment. Cox proportional hazard regression was undertaken to identify predictors of mortality. Results Of the 300 patients included in the study, 217 (72%) were ART experienced at TB diagnosis. Of these, 86 (40%) had TB within 3 months following ART initiation. Of the 83 (28%) patients who were ART-naïve at TB diagnosis, 40 (48%) were commenced on ART during TB treatment, with 24 (60%) patients commencing within 4 weeks following TB treatment initiation. The overall ART uptake was 84%, while cotrimoxazole preventive therapy uptake was 100%. There were 45 deaths (15%), ART-experienced patients during TB treatment accounted for 30 deaths (30/257; 14%), while those who were not ART-experienced during TB treatment accounted for 15 deaths (15/43; 35%). There was a significant difference in survival time between patients with no ART use during TB treatment and those with ART use during TB treatment (log rank p < 0.001). Patients with no ART use during TB treatment were more likely to die within the first 2 months. Conclusion The implementation of CPT policy is a substantial success. Strengthening the implementation of ART policy could improve survival among HIV-associated TB patients. |
| first_indexed | 2024-12-20T14:56:29Z |
| format | Article |
| id | doaj.art-55a28acaa8ca4ccc9ca6103b57b6abad |
| institution | Directory Open Access Journal |
| issn | 1471-2334 |
| language | English |
| last_indexed | 2024-12-20T14:56:29Z |
| publishDate | 2019-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Infectious Diseases |
| spelling | doaj.art-55a28acaa8ca4ccc9ca6103b57b6abad2022-12-21T19:36:49ZengBMCBMC Infectious Diseases1471-23342019-09-011911910.1186/s12879-019-4401-9Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world settingLey Muyaya Muyaya0Esperance Manwana Musanda1Jacques Lukenze Tamuzi2Palapye District Health Management Team, Department of Clinical services, Ministry of Health and wellnessDepartment of Clinical services, Princess Marina Hospital, Ministry of Health and wellnessOtavi Hospital, Ministry of Health and SocialAbstract Background Tuberculosis (TB) is among the world’s top public health challenges and the leading killer of people with HIV, yet is a treatable disease. This study aimed to assess, in a real-world setting, the implementation of antiretroviral therapy (ART) and Cotrimoxazole preventive therapy (CPT) policy, specific interventions proven to benefit patients in HIV-associated TB care. Methods This retrospective cohort study was conducted in Botswana in the Serowe/Palapye district, a largely urban district with a high burden of HIV-associated TB with a high case fatality, at Segkoma and Palapye hospitals and their feeder clinics. Between 1 January 2013 and 31 December 2013, confirmed HIV-positive patients aged ≥15 years with a confirmed TB diagnosis and medical record available were included in the analysis. The Kaplan-Meier method was used to compare time to death for the group of patients on ART and the group of patients not on ART during TB treatment. Cox proportional hazard regression was undertaken to identify predictors of mortality. Results Of the 300 patients included in the study, 217 (72%) were ART experienced at TB diagnosis. Of these, 86 (40%) had TB within 3 months following ART initiation. Of the 83 (28%) patients who were ART-naïve at TB diagnosis, 40 (48%) were commenced on ART during TB treatment, with 24 (60%) patients commencing within 4 weeks following TB treatment initiation. The overall ART uptake was 84%, while cotrimoxazole preventive therapy uptake was 100%. There were 45 deaths (15%), ART-experienced patients during TB treatment accounted for 30 deaths (30/257; 14%), while those who were not ART-experienced during TB treatment accounted for 15 deaths (15/43; 35%). There was a significant difference in survival time between patients with no ART use during TB treatment and those with ART use during TB treatment (log rank p < 0.001). Patients with no ART use during TB treatment were more likely to die within the first 2 months. Conclusion The implementation of CPT policy is a substantial success. Strengthening the implementation of ART policy could improve survival among HIV-associated TB patients.http://link.springer.com/article/10.1186/s12879-019-4401-9DeathsAIDSOutcomesMycobacterium infection |
| spellingShingle | Ley Muyaya Muyaya Esperance Manwana Musanda Jacques Lukenze Tamuzi Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting BMC Infectious Diseases Deaths AIDS Outcomes Mycobacterium infection |
| title | Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting |
| title_full | Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting |
| title_fullStr | Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting |
| title_full_unstemmed | Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting |
| title_short | Human immunodeficiency virus-associated tuberculosis care in Botswana: evidence from a real-world setting |
| title_sort | human immunodeficiency virus associated tuberculosis care in botswana evidence from a real world setting |
| topic | Deaths AIDS Outcomes Mycobacterium infection |
| url | http://link.springer.com/article/10.1186/s12879-019-4401-9 |
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