CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene
Cyclin-dependent kinase 10 (CDK10) is a CDC2-related serine/threonine kinase involved in cellular processes including cell proliferation, transcription regulation and cell cycle regulation. CDK10 has been identified as both a candidate tumor suppressor in hepatocellular carcinoma, biliary tract canc...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-06-01
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| Series: | Frontiers in Oncology |
| Subjects: | |
| Online Access: | https://www.frontiersin.org/articles/10.3389/fonc.2021.655479/full |
| _version_ | 1818907255877140480 |
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| author | Zainab A. Bazzi Zainab A. Bazzi Isabella T. Tai Isabella T. Tai |
| author_facet | Zainab A. Bazzi Zainab A. Bazzi Isabella T. Tai Isabella T. Tai |
| author_sort | Zainab A. Bazzi |
| collection | DOAJ |
| description | Cyclin-dependent kinase 10 (CDK10) is a CDC2-related serine/threonine kinase involved in cellular processes including cell proliferation, transcription regulation and cell cycle regulation. CDK10 has been identified as both a candidate tumor suppressor in hepatocellular carcinoma, biliary tract cancers and gastric cancer, and a candidate oncogene in colorectal cancer (CRC). CDK10 has been shown to be specifically involved in modulating cancer cell proliferation, motility and chemosensitivity. Specifically, in CRC, it may represent a viable biomarker and target for chemoresistance. The development of therapeutics targeting CDK10 has been hindered by lack a specific small molecule inhibitor for CDK10 kinase activity, due to a lack of a high throughput screening assay. Recently, a novel CDK10 kinase activity assay has been developed, which will aid in the development of small molecule inhibitors targeting CDK10 activity. Discovery of a small molecular inhibitor for CDK10 would facilitate further exploration of its biological functions and affirm its candidacy as a therapeutic target, specifically for CRC. |
| first_indexed | 2024-12-19T21:52:13Z |
| format | Article |
| id | doaj.art-55a2a46573d24b4d8411f452d1750848 |
| institution | Directory Open Access Journal |
| issn | 2234-943X |
| language | English |
| last_indexed | 2024-12-19T21:52:13Z |
| publishDate | 2021-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Oncology |
| spelling | doaj.art-55a2a46573d24b4d8411f452d17508482022-12-21T20:04:23ZengFrontiers Media S.A.Frontiers in Oncology2234-943X2021-06-011110.3389/fonc.2021.655479655479CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and OncogeneZainab A. Bazzi0Zainab A. Bazzi1Isabella T. Tai2Isabella T. Tai3Division of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaCanada’s Michael Smith Genome Sciences Centre, British Columbia (BC) Cancer, Vancouver, BC, CanadaDivision of Gastroenterology, Department of Medicine, University of British Columbia, Vancouver, BC, CanadaCanada’s Michael Smith Genome Sciences Centre, British Columbia (BC) Cancer, Vancouver, BC, CanadaCyclin-dependent kinase 10 (CDK10) is a CDC2-related serine/threonine kinase involved in cellular processes including cell proliferation, transcription regulation and cell cycle regulation. CDK10 has been identified as both a candidate tumor suppressor in hepatocellular carcinoma, biliary tract cancers and gastric cancer, and a candidate oncogene in colorectal cancer (CRC). CDK10 has been shown to be specifically involved in modulating cancer cell proliferation, motility and chemosensitivity. Specifically, in CRC, it may represent a viable biomarker and target for chemoresistance. The development of therapeutics targeting CDK10 has been hindered by lack a specific small molecule inhibitor for CDK10 kinase activity, due to a lack of a high throughput screening assay. Recently, a novel CDK10 kinase activity assay has been developed, which will aid in the development of small molecule inhibitors targeting CDK10 activity. Discovery of a small molecular inhibitor for CDK10 would facilitate further exploration of its biological functions and affirm its candidacy as a therapeutic target, specifically for CRC.https://www.frontiersin.org/articles/10.3389/fonc.2021.655479/fullcolorectal cancercyclin-dependent kinasesgastrointestinal cancershepatocellular carcinomagastric cancerbiliary tract cancer |
| spellingShingle | Zainab A. Bazzi Zainab A. Bazzi Isabella T. Tai Isabella T. Tai CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene Frontiers in Oncology colorectal cancer cyclin-dependent kinases gastrointestinal cancers hepatocellular carcinoma gastric cancer biliary tract cancer |
| title | CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene |
| title_full | CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene |
| title_fullStr | CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene |
| title_full_unstemmed | CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene |
| title_short | CDK10 in Gastrointestinal Cancers: Dual Roles as a Tumor Suppressor and Oncogene |
| title_sort | cdk10 in gastrointestinal cancers dual roles as a tumor suppressor and oncogene |
| topic | colorectal cancer cyclin-dependent kinases gastrointestinal cancers hepatocellular carcinoma gastric cancer biliary tract cancer |
| url | https://www.frontiersin.org/articles/10.3389/fonc.2021.655479/full |
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