The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations
Sleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited. It is therefore important to understand how these circuits operate durin...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-06-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/12/13/1761 |
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| author | Richard Teke Ngomba Annika Lüttjohann Aaron Dexter Swagat Ray Gilles van Luijtelaar |
| author_facet | Richard Teke Ngomba Annika Lüttjohann Aaron Dexter Swagat Ray Gilles van Luijtelaar |
| author_sort | Richard Teke Ngomba |
| collection | DOAJ |
| description | Sleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited. It is therefore important to understand how these circuits operate during health and disease. This review will highlight the function of mGlu5 receptors within the thalamocortical circuitry in physiological and pathological sleep states. We will also evaluate the potential of targeting mGlu5 receptors as a therapeutic strategy for sleep disorders that often co-occur with epileptic seizures. |
| first_indexed | 2024-03-11T01:45:07Z |
| format | Article |
| id | doaj.art-55a2be4d712a46d88028d073865bfa8e |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-11T01:45:07Z |
| publishDate | 2023-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-55a2be4d712a46d88028d073865bfa8e2023-11-18T16:19:40ZengMDPI AGCells2073-44092023-06-011213176110.3390/cells12131761The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical OscillationsRichard Teke Ngomba0Annika Lüttjohann1Aaron Dexter2Swagat Ray3Gilles van Luijtelaar4School of Pharmacy, University of Lincoln, Lincoln LN6 7DL, UKInstitute of Physiology I, University of Münster, 48149 Münster, GermanySchool of Pharmacy, University of Lincoln, Lincoln LN6 7DL, UKDepartment of Life Sciences, School of Life and Environmental Sciences, University of Lincoln, Lincoln LN6 7DL, UKDonders Centre for Cognition, Radboud University, 6525 XZ Nijmegen, The NetherlandsSleep is an essential innate but complex behaviour which is ubiquitous in the animal kingdom. Our knowledge of the distinct neural circuit mechanisms that regulate sleep and wake states in the brain are, however, still limited. It is therefore important to understand how these circuits operate during health and disease. This review will highlight the function of mGlu5 receptors within the thalamocortical circuitry in physiological and pathological sleep states. We will also evaluate the potential of targeting mGlu5 receptors as a therapeutic strategy for sleep disorders that often co-occur with epileptic seizures.https://www.mdpi.com/2073-4409/12/13/1761sleep and wakefulnessmetabotropic glutamate receptor 5thalamocortical oscillationsepilepsy and sleepmGlu5 receptor allosteric modulators |
| spellingShingle | Richard Teke Ngomba Annika Lüttjohann Aaron Dexter Swagat Ray Gilles van Luijtelaar The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations Cells sleep and wakefulness metabotropic glutamate receptor 5 thalamocortical oscillations epilepsy and sleep mGlu5 receptor allosteric modulators |
| title | The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations |
| title_full | The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations |
| title_fullStr | The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations |
| title_full_unstemmed | The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations |
| title_short | The Metabotropic Glutamate 5 Receptor in Sleep and Wakefulness: Focus on the Cortico-Thalamo-Cortical Oscillations |
| title_sort | metabotropic glutamate 5 receptor in sleep and wakefulness focus on the cortico thalamo cortical oscillations |
| topic | sleep and wakefulness metabotropic glutamate receptor 5 thalamocortical oscillations epilepsy and sleep mGlu5 receptor allosteric modulators |
| url | https://www.mdpi.com/2073-4409/12/13/1761 |
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