Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province
Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection,...
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| Format: | Article |
| Language: | English |
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Mashhad University of Medical Sciences
2014-10-01
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| Series: | Iranian Journal of Basic Medical Sciences |
| Subjects: | |
| Online Access: | http://ijbms.mums.ac.ir/pdf_3456_db24c5d4a1ca88ab99a639b07c0f9ae2.html |
| _version_ | 1828289480841232384 |
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| author | Amir Reza Tafreshian Mehdi Etemadi Reza Farid-Hosseini Mansoor Salhi Jalil Tavakkol Afshari |
| author_facet | Amir Reza Tafreshian Mehdi Etemadi Reza Farid-Hosseini Mansoor Salhi Jalil Tavakkol Afshari |
| author_sort | Amir Reza Tafreshian |
| collection | DOAJ |
| description | Objective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present study we examined the association between HLA-DQB1 alleles and HTLV-I infection in HAM/TSP patients, HTLV-I carriers and healthy controls in north east of Iran, Mashhad.
Materials and Methods:The blood samples of 16 patients with HAM/TSP, 20 HTLV-1 carriers, and 30 healthy individuals were taken and DNA was extracted by salting out method. HLA-DQB1 typing was performed using PCR-SSP method and the frequency of HLA-DQB1 alleles were compared by Fischer Exact Test.
Results:There was a significant difference between HAM/TSP patients and healthy controls in the frequency of HLA-DQB1*07 (P=0.004, RR=7). Furthermore, we found that possession of HLA- DQB1*02 or HLA-DQB1*05 increased the risk of disease 1.5 times.
Conclusion: The data presented here suggest that both HLA-DQB1*07 and HLA-DQB1*06 are associated with disease development. |
| first_indexed | 2024-04-13T10:21:44Z |
| format | Article |
| id | doaj.art-55a3afdbe97f4ed083e82ba185b02009 |
| institution | Directory Open Access Journal |
| issn | 2008-3866 2008-3874 |
| language | English |
| last_indexed | 2024-04-13T10:21:44Z |
| publishDate | 2014-10-01 |
| publisher | Mashhad University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Basic Medical Sciences |
| spelling | doaj.art-55a3afdbe97f4ed083e82ba185b020092022-12-22T02:50:27ZengMashhad University of Medical SciencesIranian Journal of Basic Medical Sciences2008-38662008-38742014-10-0117107988013456Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan ProvinceAmir Reza Tafreshian0Mehdi Etemadi1Reza Farid-Hosseini2Mansoor Salhi3Jalil Tavakkol Afshari4Immunology Research Group, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, IranNeurology Department and HTLVI Foundation, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, IranAllergy Research Center, School of Medicine, Mashhad University of Medical Sciences, Mashhad, IranGenetics Department School of Medicine, Isfahan University of Medical Sciences, Isfahan, IranImmunology Research Group, Bu-Ali Research Institute, Mashhad University of Medical Sciences, Mashhad, IranObjective(s): HTLVI-1 is the first human retrovirus with limited endemic regions in the world. The epidemiological studies have shown that the genetic background and immune response to the virus have a significant role in HTLV-I-associated diseases. Among the genes are involved in HTLV-I infection, the role of human leukocytes antigen (HLA) have been studied in different population. In the present study we examined the association between HLA-DQB1 alleles and HTLV-I infection in HAM/TSP patients, HTLV-I carriers and healthy controls in north east of Iran, Mashhad. Materials and Methods:The blood samples of 16 patients with HAM/TSP, 20 HTLV-1 carriers, and 30 healthy individuals were taken and DNA was extracted by salting out method. HLA-DQB1 typing was performed using PCR-SSP method and the frequency of HLA-DQB1 alleles were compared by Fischer Exact Test. Results:There was a significant difference between HAM/TSP patients and healthy controls in the frequency of HLA-DQB1*07 (P=0.004, RR=7). Furthermore, we found that possession of HLA- DQB1*02 or HLA-DQB1*05 increased the risk of disease 1.5 times. Conclusion: The data presented here suggest that both HLA-DQB1*07 and HLA-DQB1*06 are associated with disease development.http://ijbms.mums.ac.ir/pdf_3456_db24c5d4a1ca88ab99a639b07c0f9ae2.htmlHLA HLA-DQB1 HAM/TSP HTLV-1 PCR-SSP |
| spellingShingle | Amir Reza Tafreshian Mehdi Etemadi Reza Farid-Hosseini Mansoor Salhi Jalil Tavakkol Afshari Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province Iranian Journal of Basic Medical Sciences HLA HLA-DQB1 HAM/TSP HTLV-1 PCR-SSP |
| title | Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province |
| title_full | Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province |
| title_fullStr | Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province |
| title_full_unstemmed | Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province |
| title_short | Association between HLA-DQB1 alleles and HAM/TSP patients in Khorasan Province |
| title_sort | association between hla dqb1 alleles and ham tsp patients in khorasan province |
| topic | HLA HLA-DQB1 HAM/TSP HTLV-1 PCR-SSP |
| url | http://ijbms.mums.ac.ir/pdf_3456_db24c5d4a1ca88ab99a639b07c0f9ae2.html |
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