Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging
Aging is a multifunctional physiological manifestation. The nasal cavity is considered a major site for easy and cost-effective drug and vaccine administration, due to high permeability, low enzymatic activity, and the presence of a high number of immunocompetent cells. This review article primarily...
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | Biomedicines |
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| Online Access: | https://www.mdpi.com/2227-9059/11/2/354 |
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| author | Tariq Aziz Abad Ali Nadeem Abid Sarwar Ishrat Perveen Nageen Hussain Ayaz Ali Khan Zubaida Daudzai Haiying Cui Lin Lin |
| author_facet | Tariq Aziz Abad Ali Nadeem Abid Sarwar Ishrat Perveen Nageen Hussain Ayaz Ali Khan Zubaida Daudzai Haiying Cui Lin Lin |
| author_sort | Tariq Aziz |
| collection | DOAJ |
| description | Aging is a multifunctional physiological manifestation. The nasal cavity is considered a major site for easy and cost-effective drug and vaccine administration, due to high permeability, low enzymatic activity, and the presence of a high number of immunocompetent cells. This review article primarily focuses on aging genetics, physical parameters, and the use of nanoparticles as delivery systems of drugs and vaccines via the nasal cavity. Studies have identified various genes involved in centenarian and average-aged people. VEGF is a key mediator involved in angiogenesis. Different therapeutic approaches induce vascular function and angiogenesis. FOLR1 gene codes for folate receptor alpha protein that helps in regulating the transport of vitamin B folate, 5-methyltetrahydrofolate and folate analogs inside the cell. This gene also aids in slowing the aging process down by cellular regeneration and promotes healthy aging by reducing aging symptoms. It has been found through the literature that GATA 6, Yamanaka factors, and FOLR1 work in synchronization to induce healthy and delayed aging. The role and applications of genes including CBS, CISD, SIRT 1, and SIRT 6 play a significant role in aging. |
| first_indexed | 2024-03-11T09:06:52Z |
| format | Article |
| id | doaj.art-55a3f1889adb40d1b5dc773be62a43da |
| institution | Directory Open Access Journal |
| issn | 2227-9059 |
| language | English |
| last_indexed | 2024-03-11T09:06:52Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomedicines |
| spelling | doaj.art-55a3f1889adb40d1b5dc773be62a43da2023-11-16T19:16:59ZengMDPI AGBiomedicines2227-90592023-01-0111235410.3390/biomedicines11020354Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and AgingTariq Aziz0Abad Ali Nadeem1Abid Sarwar2Ishrat Perveen3Nageen Hussain4Ayaz Ali Khan5Zubaida Daudzai6Haiying Cui7Lin Lin8School of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaFood and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Centre, Lahore 54590, PakistanFood and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Centre, Lahore 54590, PakistanFood and Biotechnology Research Centre, Pakistan Council of Scientific and Industrial Research Centre, Lahore 54590, PakistanInstitute of Microbiology and Molecular Genetics, New Campus, University of the Punjab, Lahore 54590, PakistanDepartment of Biotechnology, University of Malakand, Chakdara 18800, PakistanDepartment of Bioresources and Biotechnology, King Mongkut University of Technology, Bangkok 10140, ThailandSchool of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaSchool of Food & Biological Engineering, Jiangsu University, Zhenjiang 212013, ChinaAging is a multifunctional physiological manifestation. The nasal cavity is considered a major site for easy and cost-effective drug and vaccine administration, due to high permeability, low enzymatic activity, and the presence of a high number of immunocompetent cells. This review article primarily focuses on aging genetics, physical parameters, and the use of nanoparticles as delivery systems of drugs and vaccines via the nasal cavity. Studies have identified various genes involved in centenarian and average-aged people. VEGF is a key mediator involved in angiogenesis. Different therapeutic approaches induce vascular function and angiogenesis. FOLR1 gene codes for folate receptor alpha protein that helps in regulating the transport of vitamin B folate, 5-methyltetrahydrofolate and folate analogs inside the cell. This gene also aids in slowing the aging process down by cellular regeneration and promotes healthy aging by reducing aging symptoms. It has been found through the literature that GATA 6, Yamanaka factors, and FOLR1 work in synchronization to induce healthy and delayed aging. The role and applications of genes including CBS, CISD, SIRT 1, and SIRT 6 play a significant role in aging.https://www.mdpi.com/2227-9059/11/2/354angiogenesisFOLR1GATA6nanotherapeuticsnasal drugsNALT |
| spellingShingle | Tariq Aziz Abad Ali Nadeem Abid Sarwar Ishrat Perveen Nageen Hussain Ayaz Ali Khan Zubaida Daudzai Haiying Cui Lin Lin Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging Biomedicines angiogenesis FOLR1 GATA6 nanotherapeutics nasal drugs NALT |
| title | Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging |
| title_full | Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging |
| title_fullStr | Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging |
| title_full_unstemmed | Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging |
| title_short | Particle Nanoarchitectonics for Nanomedicine and Nanotherapeutic Drugs with Special Emphasis on Nasal Drugs and Aging |
| title_sort | particle nanoarchitectonics for nanomedicine and nanotherapeutic drugs with special emphasis on nasal drugs and aging |
| topic | angiogenesis FOLR1 GATA6 nanotherapeutics nasal drugs NALT |
| url | https://www.mdpi.com/2227-9059/11/2/354 |
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