How Cardiac Embryology Translates into Clinical Arrhythmias
The electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of transcription factors that guide expression of specific...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-06-01
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| Series: | Journal of Cardiovascular Development and Disease |
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| Online Access: | https://www.mdpi.com/2308-3425/8/6/70 |
| _version_ | 1797530314069770240 |
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| author | Mathilde R. Rivaud Michiel Blok Monique R. M. Jongbloed Bastiaan J. Boukens |
| author_facet | Mathilde R. Rivaud Michiel Blok Monique R. M. Jongbloed Bastiaan J. Boukens |
| author_sort | Mathilde R. Rivaud |
| collection | DOAJ |
| description | The electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of transcription factors that guide expression of specific ion channels. Genome-wide association studies have shown that small variations in genetic regions are key to the expression of these transcription factors and thereby modulate the electrical function of the heart. Moreover, mutations in these factors are found in arrhythmogenic pathologies such as congenital atrioventricular block, as well as in specific forms of atrial fibrillation and ventricular tachycardia. In this review, we discuss the developmental origin of distinct electrophysiological structures in the heart and their involvement in cardiac arrhythmias. |
| first_indexed | 2024-03-10T10:27:16Z |
| format | Article |
| id | doaj.art-55a421f471584516a433223b031d3baf |
| institution | Directory Open Access Journal |
| issn | 2308-3425 |
| language | English |
| last_indexed | 2024-03-10T10:27:16Z |
| publishDate | 2021-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Journal of Cardiovascular Development and Disease |
| spelling | doaj.art-55a421f471584516a433223b031d3baf2023-11-21T23:56:31ZengMDPI AGJournal of Cardiovascular Development and Disease2308-34252021-06-01867010.3390/jcdd8060070How Cardiac Embryology Translates into Clinical ArrhythmiasMathilde R. Rivaud0Michiel Blok1Monique R. M. Jongbloed2Bastiaan J. Boukens3Department of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 15, 1105 AZ Amsterdam, The NetherlandsDepartment of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The NetherlandsDepartment of Anatomy & Embryology, Leiden University Medical Center, Einthovenweg 20, 2300 RC Leiden, The NetherlandsDepartment of Experimental Cardiology, Amsterdam UMC, University of Amsterdam, Amsterdam Cardiovascular Sciences, Meibergdreef 15, 1105 AZ Amsterdam, The NetherlandsThe electrophysiological signatures of the myocardium in cardiac structures, such as the atrioventricular node, pulmonary veins or the right ventricular outflow tract, are established during development by the spatial and temporal expression of transcription factors that guide expression of specific ion channels. Genome-wide association studies have shown that small variations in genetic regions are key to the expression of these transcription factors and thereby modulate the electrical function of the heart. Moreover, mutations in these factors are found in arrhythmogenic pathologies such as congenital atrioventricular block, as well as in specific forms of atrial fibrillation and ventricular tachycardia. In this review, we discuss the developmental origin of distinct electrophysiological structures in the heart and their involvement in cardiac arrhythmias.https://www.mdpi.com/2308-3425/8/6/70cardiac developmentarrhythmiasre-entrytranscription factors |
| spellingShingle | Mathilde R. Rivaud Michiel Blok Monique R. M. Jongbloed Bastiaan J. Boukens How Cardiac Embryology Translates into Clinical Arrhythmias Journal of Cardiovascular Development and Disease cardiac development arrhythmias re-entry transcription factors |
| title | How Cardiac Embryology Translates into Clinical Arrhythmias |
| title_full | How Cardiac Embryology Translates into Clinical Arrhythmias |
| title_fullStr | How Cardiac Embryology Translates into Clinical Arrhythmias |
| title_full_unstemmed | How Cardiac Embryology Translates into Clinical Arrhythmias |
| title_short | How Cardiac Embryology Translates into Clinical Arrhythmias |
| title_sort | how cardiac embryology translates into clinical arrhythmias |
| topic | cardiac development arrhythmias re-entry transcription factors |
| url | https://www.mdpi.com/2308-3425/8/6/70 |
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