Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy
Abstract Purpose To report the clinical presentations and outcome of early intravitreal injection (IVI) of octafluoropropane (C3F8) for persistent macular holes (MH) after primary pars plana vitrectomy with the internal limiting membrane (ILM) peeling technique. Methods Nineteen eyes of 18 patients...
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| Format: | Article |
| Language: | English |
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BMC
2022-09-01
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| Series: | BMC Ophthalmology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12886-022-02599-1 |
| _version_ | 1797994890488971264 |
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| author | Ying-Yi Chen Chung-May Yang |
| author_facet | Ying-Yi Chen Chung-May Yang |
| author_sort | Ying-Yi Chen |
| collection | DOAJ |
| description | Abstract Purpose To report the clinical presentations and outcome of early intravitreal injection (IVI) of octafluoropropane (C3F8) for persistent macular holes (MH) after primary pars plana vitrectomy with the internal limiting membrane (ILM) peeling technique. Methods Nineteen eyes of 18 patients with persistent MH after vitrectomy underwent intravitreal injection of C3F8 between 11 and 21 days after the initial surgery (intravitreal gas injection group). Another nine eyes with a persistent MH without additional IVI C3F8 were included (non-intravitreal gas injection group). Best-corrected visual acuity (BCVA), optical coherence tomography (OCT) features including size and configuration of MH, and time duration between the 2 surgeries were compared between the MH closure and open groups. The closure rate of persistent MHs was compared between the intravitreal gas injection group and non-intravitreal gas injection group. Results Twelve of 19 eyes (63%) achieved MH closure after 1 to 3 times IVI C3F8. The final BCVA after vitrectomy and IVI gas was significantly better in the MH closure group (P = .005). Nine of 12 patients (75%) in the MH closure group had a visual acuity improvement of more than 2 lines. Original MHs with smaller minimal diameter, higher macular hole index (MHI) and higher tractional hole index (THI); and persistent MHs with smaller minimal diameter, higher THI, and lower diameter hole index (DHI) showed higher MH closure rate. None of the persistent MHs closed in the non-intravitreal gas injection group (0/9 eyes). Conclusion Early intravitreal injection of C3F8 can be a cost-effective first-line treatment for early persistent MHs after primary surgery, especially in eyes with favorable OCT features. |
| first_indexed | 2024-04-11T09:52:57Z |
| format | Article |
| id | doaj.art-55a56dfacfeb4205ad0ba7550fda69d2 |
| institution | Directory Open Access Journal |
| issn | 1471-2415 |
| language | English |
| last_indexed | 2024-04-11T09:52:57Z |
| publishDate | 2022-09-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Ophthalmology |
| spelling | doaj.art-55a56dfacfeb4205ad0ba7550fda69d22022-12-22T04:30:45ZengBMCBMC Ophthalmology1471-24152022-09-0122111210.1186/s12886-022-02599-1Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomyYing-Yi Chen0Chung-May Yang1Department of Ophthalmology, National Taiwan University HospitalDepartment of Ophthalmology, National Taiwan University HospitalAbstract Purpose To report the clinical presentations and outcome of early intravitreal injection (IVI) of octafluoropropane (C3F8) for persistent macular holes (MH) after primary pars plana vitrectomy with the internal limiting membrane (ILM) peeling technique. Methods Nineteen eyes of 18 patients with persistent MH after vitrectomy underwent intravitreal injection of C3F8 between 11 and 21 days after the initial surgery (intravitreal gas injection group). Another nine eyes with a persistent MH without additional IVI C3F8 were included (non-intravitreal gas injection group). Best-corrected visual acuity (BCVA), optical coherence tomography (OCT) features including size and configuration of MH, and time duration between the 2 surgeries were compared between the MH closure and open groups. The closure rate of persistent MHs was compared between the intravitreal gas injection group and non-intravitreal gas injection group. Results Twelve of 19 eyes (63%) achieved MH closure after 1 to 3 times IVI C3F8. The final BCVA after vitrectomy and IVI gas was significantly better in the MH closure group (P = .005). Nine of 12 patients (75%) in the MH closure group had a visual acuity improvement of more than 2 lines. Original MHs with smaller minimal diameter, higher macular hole index (MHI) and higher tractional hole index (THI); and persistent MHs with smaller minimal diameter, higher THI, and lower diameter hole index (DHI) showed higher MH closure rate. None of the persistent MHs closed in the non-intravitreal gas injection group (0/9 eyes). Conclusion Early intravitreal injection of C3F8 can be a cost-effective first-line treatment for early persistent MHs after primary surgery, especially in eyes with favorable OCT features.https://doi.org/10.1186/s12886-022-02599-1Diameter hole indexIntravitreal gas injectionMacular hole diameterMacular hole indexOptical coherence tomographyPersistent macular hole |
| spellingShingle | Ying-Yi Chen Chung-May Yang Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy BMC Ophthalmology Diameter hole index Intravitreal gas injection Macular hole diameter Macular hole index Optical coherence tomography Persistent macular hole |
| title | Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy |
| title_full | Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy |
| title_fullStr | Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy |
| title_full_unstemmed | Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy |
| title_short | Intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy |
| title_sort | intravitreal gas injection for early persistent macular hole after primary pars plana vitrectomy |
| topic | Diameter hole index Intravitreal gas injection Macular hole diameter Macular hole index Optical coherence tomography Persistent macular hole |
| url | https://doi.org/10.1186/s12886-022-02599-1 |
| work_keys_str_mv | AT yingyichen intravitrealgasinjectionforearlypersistentmacularholeafterprimaryparsplanavitrectomy AT chungmayyang intravitrealgasinjectionforearlypersistentmacularholeafterprimaryparsplanavitrectomy |