Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing

Tetrazine-Induced Bioorthogonal Activation of Vitamin E-Modified siRNA for Gene Silencing

The temporal activation of siRNA provides a valuable strategy for the regulation of siRNA activity and conditional gene silencing. The bioorthogonal bond-cleavage reaction of benzonorbonadiene and tetrazine is a promising trigger in siRNA temporal activation. Here, we developed a new method for the...

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Bibliographic Details
Main Authors: Xueli Zhang, Amu Gubu, Jianfei Xu, Ning Yan, Wenbo Su, Di Feng, Qian Wang, Xinjing Tang
Format: Article
Language:English
Published: MDPI AG 2022-07-01
Series:Molecules
Subjects:
caged siRNA
bioorthogonal activation
siRNA
gene silencing
Online Access:https://www.mdpi.com/1420-3049/27/14/4377

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