Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review
Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection due to reactivation of John Cunningham virus (JCV). The diagnosis depends on evidence from clinical, imaging, and virologic studies. When the cerebrospinal fluid shows a negative polymerase chain reaction result, brain bi...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Korean Encephalitis and Neuroinflammation Society
2021-10-01
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| Series: | Encephalitis |
| Subjects: | |
| Online Access: | http://www.encephalitisjournal.org/upload/pdf/encephalitis-2021-00094.pdf |
| _version_ | 1818729923328606208 |
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| author | Sungjoon Yoon Yongmoo Kim Seon-Jae Ahn Kon Chu |
| author_facet | Sungjoon Yoon Yongmoo Kim Seon-Jae Ahn Kon Chu |
| author_sort | Sungjoon Yoon |
| collection | DOAJ |
| description | Progressive multifocal leukoencephalopathy (PML) is an opportunistic infection due to reactivation of John Cunningham virus (JCV). The diagnosis depends on evidence from clinical, imaging, and virologic studies. When the cerebrospinal fluid shows a negative polymerase chain reaction result, brain biopsy is required to confirm the diagnosis. PML has no standard treatment except for immune reconstitution. The anti-JCV effect of mefloquine, however, is supported by some studies, and if brain biopsy is difficult, a mefloquine trial can be considered. We describe a case of possible PML successfully treated with mefloquine. |
| first_indexed | 2024-12-17T22:53:36Z |
| format | Article |
| id | doaj.art-55a7e65f86c4482a880b4071d7d73760 |
| institution | Directory Open Access Journal |
| issn | 2765-4559 2734-1461 |
| language | English |
| last_indexed | 2024-12-17T22:53:36Z |
| publishDate | 2021-10-01 |
| publisher | Korean Encephalitis and Neuroinflammation Society |
| record_format | Article |
| series | Encephalitis |
| spelling | doaj.art-55a7e65f86c4482a880b4071d7d737602022-12-21T21:29:36ZengKorean Encephalitis and Neuroinflammation SocietyEncephalitis2765-45592734-14612021-10-011411111910.47936/encephalitis.2021.0009421Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature reviewSungjoon Yoon0Yongmoo Kim1Seon-Jae Ahn2Kon Chu3 Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, Korea Department of Neurology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul, KoreaProgressive multifocal leukoencephalopathy (PML) is an opportunistic infection due to reactivation of John Cunningham virus (JCV). The diagnosis depends on evidence from clinical, imaging, and virologic studies. When the cerebrospinal fluid shows a negative polymerase chain reaction result, brain biopsy is required to confirm the diagnosis. PML has no standard treatment except for immune reconstitution. The anti-JCV effect of mefloquine, however, is supported by some studies, and if brain biopsy is difficult, a mefloquine trial can be considered. We describe a case of possible PML successfully treated with mefloquine.http://www.encephalitisjournal.org/upload/pdf/encephalitis-2021-00094.pdfprogressive multifocal leukoencephalopathyjc virusmefloquine |
| spellingShingle | Sungjoon Yoon Yongmoo Kim Seon-Jae Ahn Kon Chu Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review Encephalitis progressive multifocal leukoencephalopathy jc virus mefloquine |
| title | Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review |
| title_full | Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review |
| title_fullStr | Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review |
| title_full_unstemmed | Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review |
| title_short | Progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review |
| title_sort | progressive multifocal leukoencephalopathy successfully treated with mefloquine and literature review |
| topic | progressive multifocal leukoencephalopathy jc virus mefloquine |
| url | http://www.encephalitisjournal.org/upload/pdf/encephalitis-2021-00094.pdf |
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