Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection?
Background: Intravenous injection of lipid emulsion propofol induces a considerable degree of pain and the most preferred treatment suggested is pretreatment with intravenous lignocaine to alleviate such pain. The present study was designed to evaluate whether addition of metoclopramide to lignocain...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2015-01-01
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| Series: | Journal of Clinical and Scientific Research |
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| Online Access: | http://svimstpt.ap.nic.in/jcsr/jan-mar15_files/3oa15.pdf |
| _version_ | 1828439263797051392 |
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| author | Girija Kumari B Samantaray A Geeta K Durga P Ramchandran G Kiran Kumar A Jagadeesh G |
| author_facet | Girija Kumari B Samantaray A Geeta K Durga P Ramchandran G Kiran Kumar A Jagadeesh G |
| author_sort | Girija Kumari B |
| collection | DOAJ |
| description | Background: Intravenous injection of lipid emulsion propofol induces a considerable degree of pain and the most preferred treatment suggested is pretreatment with intravenous lignocaine to alleviate such pain. The present study was designed to evaluate whether addition of metoclopramide to lignocaine offers any advantage over lignocaine alone as a pretreatment in prevention of pain following propofol injection.
Methods: In this prospective, randomized, double-blind controlled study, 60 patients were randomized to receive either lignocaine (group A) or lignocaine with metoclopramide (group B) intravenously as a pretreatment before injection of propofol. Pain due to injection of propofol was assessed with a four point categorical verbal rating pain scale. The incidence and magnitude of pain was compared between the two groups.
Results: There was no statistically significant difference in the perceived intensity of pain between the two groups at different time points after administration of propofol. The incidence of moderate pain was 23.3% in group A and 20% in group B (p = 0.211); 26.7% patients in group A and 43.3% patients in group B had no pain during propofol administration (p = 0.116).
Conclusions: Addition of metoclopramide to lignocaine does not have additional advantage over lignocaine alone in alleviating the pain of emulsified propofol injection. |
| first_indexed | 2024-12-10T20:20:18Z |
| format | Article |
| id | doaj.art-55a9b53dcd6b48d9ac8d1e739b094d1f |
| institution | Directory Open Access Journal |
| issn | 2277-5706 2277-8357 |
| language | English |
| last_indexed | 2024-12-10T20:20:18Z |
| publishDate | 2015-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of Clinical and Scientific Research |
| spelling | doaj.art-55a9b53dcd6b48d9ac8d1e739b094d1f2022-12-22T01:35:04ZengWolters Kluwer Medknow PublicationsJournal of Clinical and Scientific Research2277-57062277-83572015-01-01411621http://dx.doi.org/10.15380/2277-5706.JCSR.13.060Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection?Girija Kumari B0Samantaray A1Geeta K2Durga P3Ramchandran G4Kiran Kumar A5Jagadeesh G6Balaji Institute of Surgery Research Rehabilitation for Disabled, Tirupati Sri Venkateswara Institute of Medical Sciences, TirupatiNizam’s Institute of Medical Sciences, Hyderabad Nizam’s Institute of Medical Sciences, Hyderabad Nizam’s Institute of Medical Sciences, Hyderabad Sri Venkateswara Institute of Medical Sciences, TirupatiBalaji Institute of Surgery Research Rehabilitation for DisabledBackground: Intravenous injection of lipid emulsion propofol induces a considerable degree of pain and the most preferred treatment suggested is pretreatment with intravenous lignocaine to alleviate such pain. The present study was designed to evaluate whether addition of metoclopramide to lignocaine offers any advantage over lignocaine alone as a pretreatment in prevention of pain following propofol injection. Methods: In this prospective, randomized, double-blind controlled study, 60 patients were randomized to receive either lignocaine (group A) or lignocaine with metoclopramide (group B) intravenously as a pretreatment before injection of propofol. Pain due to injection of propofol was assessed with a four point categorical verbal rating pain scale. The incidence and magnitude of pain was compared between the two groups. Results: There was no statistically significant difference in the perceived intensity of pain between the two groups at different time points after administration of propofol. The incidence of moderate pain was 23.3% in group A and 20% in group B (p = 0.211); 26.7% patients in group A and 43.3% patients in group B had no pain during propofol administration (p = 0.116). Conclusions: Addition of metoclopramide to lignocaine does not have additional advantage over lignocaine alone in alleviating the pain of emulsified propofol injection.http://svimstpt.ap.nic.in/jcsr/jan-mar15_files/3oa15.pdf: LignocaineMetoclopramidePropofolPain |
| spellingShingle | Girija Kumari B Samantaray A Geeta K Durga P Ramchandran G Kiran Kumar A Jagadeesh G Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection? Journal of Clinical and Scientific Research : Lignocaine Metoclopramide Propofol Pain |
| title | Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection? |
| title_full | Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection? |
| title_fullStr | Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection? |
| title_full_unstemmed | Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection? |
| title_short | Does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection? |
| title_sort | does addition of metoclopramide to lignocaine confer additional advantage on reducing pain on propofol injection |
| topic | : Lignocaine Metoclopramide Propofol Pain |
| url | http://svimstpt.ap.nic.in/jcsr/jan-mar15_files/3oa15.pdf |
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