Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency
Abstract Background Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscl...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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BMC
2017-09-01
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| Series: | Journal of Animal Science and Biotechnology |
| Subjects: | |
| Online Access: | http://link.springer.com/article/10.1186/s40104-017-0203-3 |
| _version_ | 1818209580421742592 |
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| author | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pâmela Almeida Alexandre Miguel Henrique Santana Francisco José Novais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme José Bento Sterman Ferraz Heidge Fukumasu |
| author_facet | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pâmela Almeida Alexandre Miguel Henrique Santana Francisco José Novais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme José Bento Sterman Ferraz Heidge Fukumasu |
| author_sort | Lúcio Flávio Macedo Mota |
| collection | DOAJ |
| description | Abstract Background Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake (DMI) and average daily gain (ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake (RFI) and select 20 animals for the high feed efficient (LRFI) and 20 for the low feed efficient (HRFI) groups. Blood samples were collected on d 56 and at slaughter (80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels. Results DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness, as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter (P = 0.0049). Gene expression of leptin were greater in LRFI animals (P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression. Conclusion These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake. |
| first_indexed | 2024-12-12T05:02:58Z |
| format | Article |
| id | doaj.art-55ab717817f04850af4cd042d2ae98e5 |
| institution | Directory Open Access Journal |
| issn | 2049-1891 |
| language | English |
| last_indexed | 2024-12-12T05:02:58Z |
| publishDate | 2017-09-01 |
| publisher | BMC |
| record_format | Article |
| series | Journal of Animal Science and Biotechnology |
| spelling | doaj.art-55ab717817f04850af4cd042d2ae98e52022-12-22T00:37:11ZengBMCJournal of Animal Science and Biotechnology2049-18912017-09-01811510.1186/s40104-017-0203-3Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiencyLúcio Flávio Macedo Mota0Cristina Moreira Bonafé1Pâmela Almeida Alexandre2Miguel Henrique Santana3Francisco José Novais4Erika Toriyama5Aldrin Vieira Pires6Saulo da Luz Silva7Paulo Roberto Leme8José Bento Sterman Ferraz9Heidge Fukumasu10Departmento de Zootecnia, Universidade Federal dos Vales do Jequitinhonha e MucuriDepartmento de Zootecnia, Universidade Federal dos Vales do Jequitinhonha e MucuriDepartamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloDepartamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloDepartamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloDepartmento de Zootecnia e Desenvolvimento Agrossocioambiental Sustentável, Faculdade de Veterinária, Universidade Federal FluminenseDepartmento de Zootecnia, Universidade Federal dos Vales do Jequitinhonha e MucuriDepartamento de Zootecnia, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloDepartamento de Zootecnia, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloDepartamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloDepartamento de Medicina Veterinária, Faculdade de Zootecnia e Engenharia de Alimentos, Universidade de São PauloAbstract Background Leptin has a strong relation to important traits in animal production, such as carcass composition, feed intake, and reproduction. It is mainly produced by adipose cells and acts predominantly in the hypothalamus. In this study, circulating leptin and its gene expression in muscle were evaluated in two groups of young Nellore bulls with divergent feed efficiency. Individual dry matter intake (DMI) and average daily gain (ADG) of 98 Nellore bulls were evaluated in feedlot for 70 d to determinate the residual feed intake (RFI) and select 20 animals for the high feed efficient (LRFI) and 20 for the low feed efficient (HRFI) groups. Blood samples were collected on d 56 and at slaughter (80 d) to determine circulating plasma leptin. Samples of Longissimus dorsi were taken at slaughter for leptin gene expression levels. Results DMI and RFI were different between groups and LRFI animals showed less back fat and rump fat thickness, as well as less pelvic and kidney fat weight. Circulating leptin increased over time in all animals. Plasma leptin was greater in LRFI on 56 d and at slaughter (P = 0.0049). Gene expression of leptin were greater in LRFI animals (P = 0.0022) in accordance with the plasma levels. The animals of the LRFI group were leaner, ate less, and had more circulating leptin and its gene expression. Conclusion These findings demonstrated that leptin plays its physiological role in young Nellore bulls, probably controlling food intake because feed efficient animals have more leptin and lower residual feed intake.http://link.springer.com/article/10.1186/s40104-017-0203-3Beef cattleEnergy homeostasisFat depositonResidual feed intake |
| spellingShingle | Lúcio Flávio Macedo Mota Cristina Moreira Bonafé Pâmela Almeida Alexandre Miguel Henrique Santana Francisco José Novais Erika Toriyama Aldrin Vieira Pires Saulo da Luz Silva Paulo Roberto Leme José Bento Sterman Ferraz Heidge Fukumasu Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency Journal of Animal Science and Biotechnology Beef cattle Energy homeostasis Fat depositon Residual feed intake |
| title | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency |
| title_full | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency |
| title_fullStr | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency |
| title_full_unstemmed | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency |
| title_short | Circulating leptin and its muscle gene expression in Nellore cattle with divergent feed efficiency |
| title_sort | circulating leptin and its muscle gene expression in nellore cattle with divergent feed efficiency |
| topic | Beef cattle Energy homeostasis Fat depositon Residual feed intake |
| url | http://link.springer.com/article/10.1186/s40104-017-0203-3 |
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