Dentin defects caused by a Dspp −1 frameshift mutation are associated with the activation of autophagy

Dentin defects caused by a Dspp −1 frameshift mutation are associated with the activation of autophagy

Abstract Dentin sialophosphoprotein (DSPP) is primarily expressed by differentiated odontoblasts (dentin-forming cells), and transiently expressed by presecretory ameloblasts (enamel-forming cells). Disease-causing DSPP mutations predominantly fall into two categories: 5’ mutations affecting targeti...

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Bibliographic Details
Main Authors: Tian Liang, Charles E. Smith, Yuanyuan Hu, Hong Zhang, Chuhua Zhang, Qian Xu, Yongbo Lu, Ling Qi, Jan C.-C. Hu, James P. Simmer
Format: Article
Language:English
Published: Nature Portfolio 2023-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-33362-1

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